寻找蓖麻毒素的解毒剂

IF 3.3 3区 医学 Q2 CHEMISTRY, MEDICINAL Mini reviews in medicinal chemistry Pub Date : 2024-01-24 DOI:10.2174/0113895575270509231121060105
Fernanda Diniz Botelho, Tanos Celmar Costa Franca, Steven R. LaPlante
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引用次数: 0

摘要

蓖麻(Ricinus communis)主要因其种子而闻名,种子中含有一种名为蓖麻油酸的独特脂肪酸,具有多种工业和商业用途。蓖麻籽还含有一种被视为化学和生物战剂的毒素--蓖麻毒素。尽管经过多年的研究,目前仍然没有有效的解毒剂或疫苗。不过,目前已经取得了一些进展,有效的治疗方法可能即将问世。为了提供有关这一问题的最新概述,我们对有关抗击蓖麻毒素研究现状的文献进行了全面回顾。这篇微型综述以报告的研究为基础,旨在探讨研究人员面临的挑战,并重点介绍迄今为止最成功的案例。我们的目标是鼓励科学界在这一关键的探索中继续努力。
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The Search for Antidotes Against Ricin
The castor plant (Ricinus communis) is primarily known for its seeds, which contain a unique fatty acid called ricinoleic acid with several industrial and commercial applications. Castor seeds also contain ricin, a toxin considered a chemical and biological warfare agent. Despite years of investigation, there is still no effective antidote or vaccine available. However, some progress has been made, and the development of an effective treatment may be on the horizon. To provide an updated overview of this issue, we have conducted a comprehensive review of the literature on the current state of research in the fight against ricin. This mini-review is based on the reported research and aims to address the challenges faced by researchers, as well as highlight the most successful cases achieved thus far. Our goal is to encourage the scientific community to continue their efforts in this critical search.
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来源期刊
CiteScore
7.80
自引率
0.00%
发文量
231
审稿时长
6 months
期刊介绍: The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.
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