P479 肠道白塞氏病患者血液恶性肿瘤的发病率和风险因素

S Choi, J H Ji, S J Park, J J Park, J H Cheon, T I Kim, J Park
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Eight patients had developed hematologic malignancy before their intestinal BD diagnosis and 15 patients developed hematologic malignancy after their intestinal BD diagnosis. Of the 772 patients without previous hematologic malignancy, patients smoking history (p-value 0.019, odds ratio [OR] 49.513, 95% confidence interval [CI] 1.925-1273.4), history of at least one emergency room (ER) visit (p-value 0.025, OR 26.360, CI 1.501-462.92), and albumin lower than 3.3g/dL (p-value 0.046, OR 603.013, CI 0.108-328191.23) at diagnosis were positively associated with subsequent hematologic malignancy. Body mass index (BMI) (p-value 0.030, OR 0.569, CI 0.342-0.947) was negatively associated with hematologic malignancy. 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摘要

背景 肠白塞氏病(BD)与血液系统恶性肿瘤风险的关系尚不清楚。我们旨在评估肠道白塞氏病的患病率并确定血液系统恶性肿瘤的风险因素。方法 韩国首尔 Severance 医院炎症性肠病中心利用 1997 年至 2021 年间的肠道 BD 患者队列,通过逻辑回归分析法对血液系统恶性肿瘤的患病率和风险因素进行了分析。结果 在 780 名肠道 BD 患者中,有 23 人罹患血液系统恶性肿瘤。骨髓增生异常综合征(MDS)(12 人)是最常见的血液系统恶性肿瘤,其次是再生障碍性贫血(AA)(7 人)、白血病(2 人)和淋巴瘤(2 人)。8 名患者在确诊肠道 BD 之前就已罹患血液系统恶性肿瘤,15 名患者在确诊肠道 BD 之后罹患血液系统恶性肿瘤。在 772 例既往未患血液系统恶性肿瘤的患者中,吸烟史(P 值 0.019,几率比 [OR] 49.513,95% 置信区间 [CI]1.925-1273.4)、至少一次急诊室就诊史(P 值 0.025,OR 26.360,CI 1.501-462.92)、诊断时白蛋白低于 3.3g/dL(p 值 0.046,OR 603.013,CI 0.108-328191.23)与随后的血液系统恶性肿瘤呈正相关。体重指数(BMI)(p-value 0.030,OR 0.569,CI 0.342-0.947)与血液恶性肿瘤呈负相关。结论 为具有危险因素的肠道 BD 患者提供护理的医生应了解血液恶性肿瘤风险升高的情况,并进行仔细监测。
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P479 The prevalence and risk factors of hematologic malignancy in patients with intestinal Behçet’s disease
Background The association of intestinal Behçet’s disease (BD) with the risk of hematologic malignancy is still unclear. We aimed to assess the prevalence and determine risk factors of hematologic malignancy in intestinal BD. Methods Using a cohort of patients with intestinal BD between 1997 and 2021, the prevalence and risk factors of hematologic malignancy were analysed by logistic regression analysis at inflammatory bowel disease centre of Severance Hospital, Seoul, Korea. Results Among 780 intestinal BD patients, 23 patients developed hematologic malignancy. Myelodysplastic syndrome (MDS) (n=12) was the most common hematologic malignancy, followed by aplastic anemia (AA) (n=7), leukemia (n=2), and lymphoma (n=2). Eight patients had developed hematologic malignancy before their intestinal BD diagnosis and 15 patients developed hematologic malignancy after their intestinal BD diagnosis. Of the 772 patients without previous hematologic malignancy, patients smoking history (p-value 0.019, odds ratio [OR] 49.513, 95% confidence interval [CI] 1.925-1273.4), history of at least one emergency room (ER) visit (p-value 0.025, OR 26.360, CI 1.501-462.92), and albumin lower than 3.3g/dL (p-value 0.046, OR 603.013, CI 0.108-328191.23) at diagnosis were positively associated with subsequent hematologic malignancy. Body mass index (BMI) (p-value 0.030, OR 0.569, CI 0.342-0.947) was negatively associated with hematologic malignancy. Conclusion The physicians who care for intestinal BD patients with risk factors should be aware and provide careful monitoring of the elevated risk of hematologic malignancy.
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