二甲双胍、西格列汀和恩格列净初始三联疗法对药物无效的 2 型糖尿病患者的两年疗效和安全性。

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Diabetes & Metabolism Journal Pub Date : 2024-03-01 Epub Date: 2024-01-26 DOI:10.4093/dmj.2023.0128
Young-Hwan Park, Minji Sohn, So Yeon Lee, Soo Lim
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引用次数: 0

摘要

背景我们研究了2型糖尿病患者使用二甲双胍、二肽基肽酶-4抑制剂和钠-葡萄糖共转运体-2抑制剂进行初始三联疗法的长期疗效和安全性:我们招募了170名糖化血红蛋白(HbA1c)水平大于7.5%、开始接受三联疗法(二甲双胍、西格列汀和恩格列净)的药物过敏患者。在 24 个月内测量了血糖、代谢和尿液参数:24个月后,HbA1c水平从11.0%±1.8%大幅降至7.0%±1.7%。在12个月和24个月时,血糖目标(HbA1c)的达标率分别为(1.0%±1.8%)和(1.0%±1.7%):使用二甲双胍、西格列汀和恩格列净的初始三联疗法可实现血糖目标,并可维持24个月,且无严重低血糖,代谢功能和白蛋白尿也有所改善。对于药物治疗无效的2型糖尿病患者来说,这种联合疗法可能是一种不错的策略。
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Two-Year Therapeutic Efficacy and Safety of Initial Triple Combination of Metformin, Sitagliptin, and Empagliflozin in Drug-Naïve Type 2 Diabetes Mellitus Patients.

Backgruound: We investigated the long-term efficacy and safety of initial triple therapy using metformin, a dipeptidyl peptidase-4 inhibitor, and a sodium-glucose cotransporter-2 inhibitor, in patients with type 2 diabetes mellitus.

Methods: We enrolled 170 drug-naïve patients with glycosylated hemoglobin (HbA1c) level >7.5% who had started triple therapy (metformin, sitagliptin, and empagliflozin). Glycemic, metabolic, and urinary parameters were measured for 24 months.

Results: After 24 months, HbA1c level decreased significantly from 11.0%±1.8% to 7.0%±1.7%. At 12 and 24 months, the rates of achievement of the glycemic target goal (HbA1c <7.0%) were 72.5% and 61.7%, respectively, and homeostasis model assessment of β-cell function and insulin resistance indices improved. Whole-body fat percentage decreased by 1.08%, and whole-body muscle percentage increased by 0.97% after 24 months. Fatty liver indices and albuminuria improved significantly. The concentration of ketone bodies was elevated at the baseline but decreased after 24 months. There were no serious adverse events, including ketoacidosis.

Conclusion: Initial triple combination therapy with metformin, sitagliptin, and empagliflozin led to achievement of the glycemic target goal, which was maintained for 24 months without severe hypoglycemia but with improved metabolic function and albuminuria. This combination therapy may be a good strategy for drug-naïve patients with type 2 diabetes mellitus.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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