Sewhan Na, Jong-Tae Park, Seungbeom Kim, Jinwoo Han, Saemi Jung, Kyeongmin Kwak
{"title":"环境颗粒物水平与高血压之间的关系：韩国基因组与流行病学研究的结果。","authors":"Sewhan Na, Jong-Tae Park, Seungbeom Kim, Jinwoo Han, Saemi Jung, Kyeongmin Kwak","doi":"10.35371/aoem.2023.35.e51","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure.</p><p><strong>Methods: </strong>A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas.</p><p><strong>Results: </strong>Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM<sub>10</sub> (particulate matter with diameters < 10 μm) and PM<sub>2.5</sub> (particulate matter with diameters < 2.5 μm) levels over the long-term period and all high PM<sub>10</sub> and PM<sub>2.5</sub> levels were statistically significant after adjusting for various covariates. Notably, high PM<sub>2.5</sub> levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment.</p><p><strong>Conclusions: </strong>These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.</p>","PeriodicalId":46631,"journal":{"name":"Annals of Occupational and Environmental Medicine","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808086/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study.\",\"authors\":\"Sewhan Na, Jong-Tae Park, Seungbeom Kim, Jinwoo Han, Saemi Jung, Kyeongmin Kwak\",\"doi\":\"10.35371/aoem.2023.35.e51\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure.</p><p><strong>Methods: </strong>A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas.</p><p><strong>Results: </strong>Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM<sub>10</sub> (particulate matter with diameters < 10 μm) and PM<sub>2.5</sub> (particulate matter with diameters < 2.5 μm) levels over the long-term period and all high PM<sub>10</sub> and PM<sub>2.5</sub> levels were statistically significant after adjusting for various covariates. Notably, high PM<sub>2.5</sub> levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment.</p><p><strong>Conclusions: </strong>These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.</p>\",\"PeriodicalId\":46631,\"journal\":{\"name\":\"Annals of Occupational and Environmental Medicine\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2023-12-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10808086/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Occupational and Environmental Medicine\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.35371/aoem.2023.35.e51\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Occupational and Environmental Medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.35371/aoem.2023.35.e51","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH","Score":null,"Total":0}
Association between ambient particulate matter levels and hypertension: results from the Korean Genome and Epidemiology Study.
Background: Recently, there has been increasing worldwide concern about outdoor air pollution, especially particulate matter (PM), which has been extensively researched for its harmful effects on the respiratory system. However, sufficient research on its effects on cardiovascular diseases, such as hypertension, remains lacking. In this study, we examine the associations between PM levels and hypertension and hypothesize that higher PM concentrations are associated with elevated blood pressure.
Methods: A total of 133,935 adults aged ≥ 40 years who participated in the Korean Genome and Epidemiology Study were analyzed. Multiple linear regression analyses were conducted to investigate the short- (1-14 days), medium- (1 and 3 months), and long-term (1 and 2 years) impacts of PM on blood pressure. Logistic regression analyses were conducted to evaluate the medium- and long-term effects of PM on blood pressure elevation after adjusting for sex, age, body mass index, health-related lifestyle behaviors, and geographic areas.
Results: Using multiple linear regression analyses, both crude and adjusted models generated positive estimates, indicating an association with increased blood pressure, with all results being statistically significant, with the exception of PM levels over the long-term period (1 and 2 years) in non-hypertensive participants. In the logistic regression analyses on non-hypertensive participants, moderate PM10 (particulate matter with diameters < 10 μm) and PM2.5 (particulate matter with diameters < 2.5 μm) levels over the long-term period and all high PM10 and PM2.5 levels were statistically significant after adjusting for various covariates. Notably, high PM2.5 levels of the 1 year exhibited the highest odds ratio of 1.23 (95% confidence interval: 1.19-1.28) after adjustment.
Conclusions: These findings suggest that both short- and long-term exposure to PM is associated with blood pressure elevation.
期刊介绍：
Annals of Occupational and Environmental Medicine (AOEM) is an open access journal that considers original contributions relevant to occupational and environmental medicine and related fields, in the form of original articles, review articles, short letters and case reports. AOEM is aimed at clinicians and researchers working in the wide-ranging discipline of occupational and environmental medicine. Topic areas focus on, but are not limited to, interactions between work and health, covering occupational and environmental epidemiology, toxicology, hygiene, diagnosis and treatment of diseases, management, organization and policy. As the official journal of the Korean Society of Occupational and Environmental Medicine (KSOEM), members and authors based in the Republic of Korea are entitled to a discounted article-processing charge when they publish in AOEM.
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