欧米克隆突破性感染与单价 SARS-CoV-2 肌肉注射增强剂的比较揭示了粘膜和全身体液免疫的差异。

IF 7.9 2区 医学 Q1 IMMUNOLOGY Mucosal Immunology Pub Date : 2024-04-01 DOI:10.1016/j.mucimm.2024.01.004
Sabryna Nantel , Salma Sheikh-Mohamed , Gary Y.C. Chao , Alexandra Kurtesi , Queenie Hu , Heidi Wood , Karen Colwill , Zhijie Li , Ying Liu , Laurie Seifried , Benoîte Bourdin , Allison McGeer , William R. Hardy , Olga L. Rojas , Tho-Alfakar Al-Aubodah , Zhiyang Liu , Mario A. Ostrowski , Mark A. Brockman , Ciriaco A. Piccirillo , Caroline Quach , Jennifer L. Gommerman
{"title":"欧米克隆突破性感染与单价 SARS-CoV-2 肌肉注射增强剂的比较揭示了粘膜和全身体液免疫的差异。","authors":"Sabryna Nantel ,&nbsp;Salma Sheikh-Mohamed ,&nbsp;Gary Y.C. Chao ,&nbsp;Alexandra Kurtesi ,&nbsp;Queenie Hu ,&nbsp;Heidi Wood ,&nbsp;Karen Colwill ,&nbsp;Zhijie Li ,&nbsp;Ying Liu ,&nbsp;Laurie Seifried ,&nbsp;Benoîte Bourdin ,&nbsp;Allison McGeer ,&nbsp;William R. Hardy ,&nbsp;Olga L. Rojas ,&nbsp;Tho-Alfakar Al-Aubodah ,&nbsp;Zhiyang Liu ,&nbsp;Mario A. Ostrowski ,&nbsp;Mark A. Brockman ,&nbsp;Ciriaco A. Piccirillo ,&nbsp;Caroline Quach ,&nbsp;Jennifer L. Gommerman","doi":"10.1016/j.mucimm.2024.01.004","DOIUrl":null,"url":null,"abstract":"<div><p>Our understanding of the quality of cellular and humoral immunity conferred by COVID-19 vaccination alone versus vaccination plus SARS-CoV-2 breakthrough (BT) infection remains incomplete. While the current (2023) SARS-CoV-2 immune landscape of Canadians is complex, in late 2021 most Canadians had either just received a third dose of COVID-19 vaccine, or had received their two-dose primary series and then experienced an Omicron BT. Herein we took advantage of this coincident timing to contrast cellular and humoral immunity conferred by three doses of vaccine versus two doses plus BT. Our results show thatBT infection induces cell-mediated immune responses to variants comparable to an intramuscular vaccine booster dose. In contrast, BT subjects had higher salivary immunoglobulin (Ig)G and IgA levels against the Omicron spike and enhanced reactivity to the ancestral spike for the IgA isotype, which also reacted with SARS-CoV-1. Serumneutralizing antibody levels against the ancestral strain and the variants were also higher after BT infection. Our results support the need for the development of intranasal vaccines that could emulate the enhanced mucosal and humoral immunity induced by Omicron BT without exposing individuals to the risks associated with SARS-CoV-2 infection.</p></div>","PeriodicalId":18877,"journal":{"name":"Mucosal Immunology","volume":"17 2","pages":"Pages 201-210"},"PeriodicalIF":7.9000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1933021924000047/pdfft?md5=2d844e1ed81ce93c27def9b02d042c8e&pid=1-s2.0-S1933021924000047-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity\",\"authors\":\"Sabryna Nantel ,&nbsp;Salma Sheikh-Mohamed ,&nbsp;Gary Y.C. Chao ,&nbsp;Alexandra Kurtesi ,&nbsp;Queenie Hu ,&nbsp;Heidi Wood ,&nbsp;Karen Colwill ,&nbsp;Zhijie Li ,&nbsp;Ying Liu ,&nbsp;Laurie Seifried ,&nbsp;Benoîte Bourdin ,&nbsp;Allison McGeer ,&nbsp;William R. Hardy ,&nbsp;Olga L. Rojas ,&nbsp;Tho-Alfakar Al-Aubodah ,&nbsp;Zhiyang Liu ,&nbsp;Mario A. Ostrowski ,&nbsp;Mark A. Brockman ,&nbsp;Ciriaco A. Piccirillo ,&nbsp;Caroline Quach ,&nbsp;Jennifer L. Gommerman\",\"doi\":\"10.1016/j.mucimm.2024.01.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Our understanding of the quality of cellular and humoral immunity conferred by COVID-19 vaccination alone versus vaccination plus SARS-CoV-2 breakthrough (BT) infection remains incomplete. While the current (2023) SARS-CoV-2 immune landscape of Canadians is complex, in late 2021 most Canadians had either just received a third dose of COVID-19 vaccine, or had received their two-dose primary series and then experienced an Omicron BT. Herein we took advantage of this coincident timing to contrast cellular and humoral immunity conferred by three doses of vaccine versus two doses plus BT. Our results show thatBT infection induces cell-mediated immune responses to variants comparable to an intramuscular vaccine booster dose. In contrast, BT subjects had higher salivary immunoglobulin (Ig)G and IgA levels against the Omicron spike and enhanced reactivity to the ancestral spike for the IgA isotype, which also reacted with SARS-CoV-1. Serumneutralizing antibody levels against the ancestral strain and the variants were also higher after BT infection. Our results support the need for the development of intranasal vaccines that could emulate the enhanced mucosal and humoral immunity induced by Omicron BT without exposing individuals to the risks associated with SARS-CoV-2 infection.</p></div>\",\"PeriodicalId\":18877,\"journal\":{\"name\":\"Mucosal Immunology\",\"volume\":\"17 2\",\"pages\":\"Pages 201-210\"},\"PeriodicalIF\":7.9000,\"publicationDate\":\"2024-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S1933021924000047/pdfft?md5=2d844e1ed81ce93c27def9b02d042c8e&pid=1-s2.0-S1933021924000047-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Mucosal Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1933021924000047\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mucosal Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1933021924000047","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

我们对单独接种 2019 年冠状病毒病(COVID-19)疫苗与接种疫苗加严重急性呼吸系统综合症冠状病毒 2(SARS-CoV-2)突破性 (BT) 感染所产生的细胞和体液免疫质量的了解仍不全面。虽然加拿大人目前(2023 年)的 SARS-CoV-2 免疫状况很复杂,但在 2021 年末,大多数加拿大人要么刚刚接种了第三剂 COVID-19 疫苗,要么接种了两剂初级系列疫苗,然后经历了一次 Omicron BT。在此,我们利用这一巧合时机,对比了接种三剂疫苗与接种两剂疫苗加 BT 所产生的细胞免疫和体液免疫。我们的研究结果表明,轻度 BT 感染诱导的细胞介导免疫反应变异与肌肉注射疫苗加强剂量相当。与此相反,BT 受试者唾液中针对 Omicron 穗状病毒的 IgG 和 IgA 水平较高,对祖先穗状病毒的 IgA 同工型反应性增强,后者也与 SARS-CoV-1 发生反应。BT 感染后,血清中针对祖先株和变异株的中和抗体水平也较高。我们的研究结果支持了对疫苗的需求,这种疫苗既能增强 Omicron BT 诱导的粘膜免疫和体液免疫,又不会使人面临感染 SARS-CoV-2 的风险。一句话总结 Omicron BT 可在接种疫苗的成年人中引起交叉反应性全身和粘膜免疫反应。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Comparison of Omicron breakthrough infection versus monovalent SARS-CoV-2 intramuscular booster reveals differences in mucosal and systemic humoral immunity

Our understanding of the quality of cellular and humoral immunity conferred by COVID-19 vaccination alone versus vaccination plus SARS-CoV-2 breakthrough (BT) infection remains incomplete. While the current (2023) SARS-CoV-2 immune landscape of Canadians is complex, in late 2021 most Canadians had either just received a third dose of COVID-19 vaccine, or had received their two-dose primary series and then experienced an Omicron BT. Herein we took advantage of this coincident timing to contrast cellular and humoral immunity conferred by three doses of vaccine versus two doses plus BT. Our results show thatBT infection induces cell-mediated immune responses to variants comparable to an intramuscular vaccine booster dose. In contrast, BT subjects had higher salivary immunoglobulin (Ig)G and IgA levels against the Omicron spike and enhanced reactivity to the ancestral spike for the IgA isotype, which also reacted with SARS-CoV-1. Serumneutralizing antibody levels against the ancestral strain and the variants were also higher after BT infection. Our results support the need for the development of intranasal vaccines that could emulate the enhanced mucosal and humoral immunity induced by Omicron BT without exposing individuals to the risks associated with SARS-CoV-2 infection.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Mucosal Immunology
Mucosal Immunology 医学-免疫学
CiteScore
16.60
自引率
3.80%
发文量
100
审稿时长
12 days
期刊介绍: Mucosal Immunology, the official publication of the Society of Mucosal Immunology (SMI), serves as a forum for both basic and clinical scientists to discuss immunity and inflammation involving mucosal tissues. It covers gastrointestinal, pulmonary, nasopharyngeal, oral, ocular, and genitourinary immunology through original research articles, scholarly reviews, commentaries, editorials, and letters. The journal gives equal consideration to basic, translational, and clinical studies and also serves as a primary communication channel for the SMI governing board and its members, featuring society news, meeting announcements, policy discussions, and job/training opportunities advertisements.
期刊最新文献
Activation of α2B/2C adrenergic receptor ameliorates ocular surface inflammation through enhancing regulatory T cell function. Pro-inflammatory NK-like T cells are expanded in the blood and inflamed intestine in Crohn's disease. Airway macrophage glycolysis controls lung homeostasis and responses to aeroallergen. RelB and C/EBPα critically regulate the development of Peyer's patch mononuclear phagocytes. TRIM29 controls enteric RNA virus-induced intestinal inflammation by targeting NLRP6 and NLRP9b signaling pathways.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1