LRRK2;在帕金森病和溃疡性结肠炎治疗中的沟通作用重叠。

Naser-Aldin Lashgari, Nazanin Momeni Roudsari, Amirhossein Niknejad, Hedieh Sadat Shamsnia, Maryam Shayan, Leila Mohaghegh Shalmani, Saeideh Momtaz, Nima Rezaei, Amir Hossein Abdolghaffari
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引用次数: 0

摘要

背景:胃肠道炎症与帕金森病(PD)发病机制和运动的关系逐渐浮出水面。炎症涉及帕金森病和炎症性肠病(IBD)的病因。富亮氨酸复性激酶 2(LRRK2)的转变是 IBD 和 PD 的最佳遗传支持因素之一。据报道,在IBD患者受刺激的结肠组织和不规则PD患者的外周无损细胞中,LRRK2水平升高;因此,人们认为LRRK2引导炎症循环:LRRK2自被揭示以来,一直与神经元密切相关,尽管各种证据都证实LRRK2在无创细胞中具有深远的沟通作用。因此,LRRK2可能位于胃部炎症的交界处,IBD中较高的LRRK2水平可能是不一致的PD风险扩大的生物标志物,或者可能在增加PD风险的传染性疾病中解决一个可管理的有用目标。在此,我们讨论了PD和IBD如何共同覆盖聚集,特别是关于LRRK2和目前的抑制剂,这可能是正在进行的治疗中的一个有用的目标:从谷歌学术、PubMed、Scopus和Cochrane图书馆1990年至2022年12月间发表的研究中获取英文数据:结果:LRRK2通路抑制剂可被视为治疗IBD和PD的新型治疗方法:IBD和PD的病理生理学涉及共同的介质和通路,它们主要与炎症情况相关。这些疾病可用于进一步的临床研究。
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LRRK2; Communicative Role in the Treatment of Parkinson's Disease and Ulcerative Colitis Overlapping.

Background: Involvement of gastrointestinal inflammation in Parkinson's disease (PD) pathogenesis and movement have progressively emerged. Inflammation is involved in the etiology of both PD and inflammatory bowel disease (IBD). Transformations in leucine-rich recurrent kinase 2 (LRRK2) are among the best hereditary supporters of IBD and PD. Elevated levels of LRRK2 have been reported in stimulated colonic tissue from IBD patients and peripheral invulnerable cells from irregular PD patients; thus, it is thought that LRRK2 directs inflammatory cycles.

Objective: Since its revelation, LRRK2 has been seriously linked in neurons, albeit various lines of proof affirmed that LRRK2 is profoundly communicated in invulnerable cells. Subsequently, LRRK2 might sit at a junction by which stomach inflammation and higher LRRK2 levels in IBD might be a biomarker of expanded risk for inconsistent PD or potentially may address a manageable helpful objective in incendiary sicknesses that increment the risk of PD. Here, we discuss how PD and IBD share covering aggregates, especially regarding LRRK2 and present inhibitors, which could be a helpful objective in ongoing treatments.

Method: English data were obtained from Google Scholar, PubMed, Scopus, and Cochrane library studies published between 1990-December 2022.

Result: Inhibitors of the LRRK2 pathway can be considered as the novel treatment approaches for IBD and PD treatment.

Conclusion: Common mediators and pathways are involved in the pathophysiology of IBD and PD, which are majorly correlated with inflammatory situations. Such diseases could be used for further clinical investigations.

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