作为胶质母细胞瘤 Notch 信号通路关键调控因子的非编码 RNA:诊断、预后和治疗靶点。

Seyed Hossein Shahcheraghi, Elmira Roshani Asl, Malihe Lotfi, Jamshid Ayatollahi, Seyed Hossein Khaleghinejad, Alaa A A Aljabali, Hamid A Bakshi, Mohamed El-Tanani, Nitin B Charbe, Ángel Serrano-Aroca, Vijay Mishra, Yachana Mishra, Rohit Goyal, Altijana Hromić-Jahjefendić, Vladimir N Uversky, Marzieh Lotfi, Murtaza M Tambuwala
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引用次数: 0

摘要

多形性胶质母细胞瘤(GBM)是一种源自星形胶质细胞的高侵袭性脑恶性肿瘤,约占中枢神经系统恶性肿瘤的 30%。尽管手术、化疗和放射性药物等治疗策略取得了进展,但 GBM 患者的预后仍然不容乐观。鉴于 GBM 的侵袭性,有必要确定分子靶点并探索有效的治疗方法来抑制其增殖。Notch 信号通路在细胞稳态中发挥着关键作用,但在 GBM 中却出现失调,导致 MYC、Hes1 和 Hey1 等通路靶基因表达增加,从而促进细胞增殖和分化。最近的研究强调了非编码 RNA(ncRNA)通过在转录后或转录水平靶向关键 mRNA 表达来调节 Notch 信号转导的调控作用。具体来说,各种类型的 ncRNA(包括长非编码 RNA(lncRNA)和 microRNA(miRNA))已被证明可控制多个靶基因,并在很大程度上导致 GBM 癌变。此外,这些 ncRNA 还有望成为 GBM 的预后和预测标志物。本综述旨在总结有关 ncRNA 对 GBM 中 Notch 信号通路的调控作用的最新研究。
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Non-coding RNAs as Key Regulators of the Notch Signaling Pathway in Glioblastoma: Diagnostic, Prognostic, and Therapeutic Targets.

Glioblastoma multiforme (GBM) is a highly invasive brain malignancy originating from astrocytes, accounting for approximately 30% of central nervous system malignancies. Despite advancements in therapeutic strategies including surgery, chemotherapy, and radiopharmaceutical drugs, the prognosis for GBM patients remains dismal. The aggressive nature of GBM necessitates the identification of molecular targets and the exploration of effective treatments to inhibit its proliferation. The Notch signaling pathway, which plays a critical role in cellular homeostasis, becomes deregulated in GBM, leading to increased expression of pathway target genes such as MYC, Hes1, and Hey1, thereby promoting cellular proliferation and differentiation. Recent research has highlighted the regulatory role of non-coding RNAs (ncRNAs) in modulating Notch signaling by targeting critical mRNA expression at the post-transcriptional or transcriptional levels. Specifically, various types of ncRNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), have been shown to control multiple target genes and significantly contribute to the carcinogenesis of GBM. Furthermore, these ncRNAs hold promise as prognostic and predictive markers for GBM. This review aims to summarize the latest studies investigating the regulatory effects of ncRNAs on the Notch signaling pathway in GBM.

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