瑞舒伐他汀对凝血因子和同型半胱氨酸水平的影响能否降低高胆固醇血症患者的血栓风险?

Mostafa Behnam, Mohammad Reza Deyhim, Parichehreh Yaghmaei
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引用次数: 0

摘要

背景和目的:高胆固醇血症是导致血管血栓形成的主要危险因素之一。因此,使用他汀类药物能有效降低胆固醇,减少这些患者的血栓风险。瑞舒伐他汀是他汀类药物家族中的一员,它能抑制胆固醇的合成。关于瑞舒伐他汀如何影响血栓形成的研究很少。因此,本研究试图探讨罗伐他汀是否会对作为高胆固醇血症血栓形成危险因素的凝血因子和同型半胱氨酸产生影响?在这项实验研究中,60 名确诊为高胆固醇血症(胆固醇大于 250 毫克/分升)的患者(30 名男性和 30 名女性,平均年龄 40-70 岁)参与了研究。30 名患者服用罗伐他汀(20 毫克/天),30 名患者同时服用安慰剂三个月。在治疗前后测量了所有参数,包括 FVIII、FV、纤维蛋白原、D-二聚体、血浆同型半胱氨酸水平和血脂概况。对两组患者的所有结果进行统计比较:结果:服用罗伐他汀的患者,总胆固醇、甘油三酯、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)的浓度明显降低(P 0.05):根据研究结果,洛伐他汀似乎可以通过影响凝血因子和同型半胱氨酸水平来降低患者血栓形成的风险。
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Can Rosuvastatin Reduce the Risk of Thrombosis in Patients with Hypercholesterolemia with its Effect on Coagulation Factors and Homocysteine Levels?

Background and objectives: Hypercholesterolemia is one of the main risk factors for vascular thrombosis in individuals. Therefore, the use of statins is very effective in reducing cholesterol and can reduce the risk of thrombosis in these patients. Rosuvastatin, a member of the statin family which, inhibits cholesterol synthesis. Very few studies have been done in relation to how rosuvastatin can affect thrombosis. So, this research has been tried whether rosuvastatin can have an effect on coagulation factors and homocysteine as risk factors for thrombosis in hypercholesterolemia?

Methods: In this experimental study, 60 patients (30 men and 30 women with a mean age of 40- 70 years) diagnosed with hypercholesterolemia (cholesterol > 250 mg/dl) participated in this research. 30 patients were prescribed rosuvastatin (20 mg/day), and 30 patients were simultaneously taken placebo for three months. All parameters, including FVIII, FV, Fibrinogen, DDimer, plasma homocysteine level and lipid profile, were measured before and after treatment. All the results were statistically compared between the two groups.

Results: In patients who took rosuvastatin, the drug was able to significantly reduce the concentrations of total cholesterol, triglycerides, and low-density lipoprotein (LDL) (P < 0.001). Also, rosuvastatin was able to reduce the concentrations of homocysteine significantly, D-Dimer (P < 0.001), coagulation factor VIII and factor V (P < 0.05). In patients with hypercholesterolemia who took the placebo, did not affect the mentioned variables (P > 0.05).

Conclusion: According to the results, it seems that rosuvastatin may be able to reduce the risk of thrombosis in patients by affecting coagulation factors and homocysteine levels.

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