纳米粒子在皮肤组织工程中的应用:当前概念与未来展望。

Maryam Kaviani, Bita Geramizadeh
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引用次数: 0

摘要

纳米技术似乎为皮肤组织工程中尚未解决的复杂问题提供了解决方案。根据纳米粒子的广泛功能,这篇综述文章旨在为皮肤组织工程的未来成功构建一个视角。本综述回顾了最近的研究,总结了纳米粒子在皮肤组织工程中应用的基本优势和挑战性问题。以往的研究表明,纳米粒子在改善工程皮肤方面可发挥重要作用。工程皮肤结构的生物启发设计首先需要了解原生组织,并在实验室条件下模拟原生组织。此外,从根本上了解纳米粒子及其对最终结构的相关影响,可以指导研究人员寻找合适的纳米粒子。注意基本细节,包括根据支架指定纳米粒子类型、如何制备纳米粒子以及使用何种浓度的纳米粒子,对于纳米粒子的应用成为现实至关重要。总之,应用纳米粒子可促进支架特性和血管生成、改善细胞行为、提供抗菌条件和细胞追踪。
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Nanoparticles' Perspective in Skin Tissue Engineering: Current Concepts and Future Outlook.

Nanotechnology seems to provide solutions to the unresolved complications in skin tissue engineering. According to the broad function of nanoparticles, this review article is intended to build a perspective for future success in skin tissue engineering. In the present review, recent studies were reviewed, and essential benefits and challenging issues regarding the application of nanoparticles in skin tissue engineering were summarized. Previous studies indicated that nanoparticles can play essential roles in the improvement of engineered skin. Bio-inspired design of an engineered skin structure first needs to understand the native tissue and mimic that in laboratory conditions. Moreover, a fundamental comprehension of the nanoparticles and their related effects on the final structure can guide researchers in recruiting appropriate nanoparticles. Attention to essential details, including the designation of nanoparticle type according to the scaffold, how to prepare the nanoparticles, and what concentration to use, is critical for the application of nanoparticles to become a reality. In conclusion, nanoparticles were applied to promote scaffold characteristics and angiogenesis, improve cell behavior, provide antimicrobial conditions, and cell tracking.

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