青少年吸食大麻与焦虑症状和焦虑症:系统回顾和荟萃分析。

IF 2.7 3区 医学 Q2 PSYCHOLOGY, CLINICAL American Journal of Drug and Alcohol Abuse Pub Date : 2024-03-03 Epub Date: 2024-01-29 DOI:10.1080/00952990.2023.2299922
Darby J E Lowe, Maryam Sorkhou, Tony P George
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引用次数: 0

摘要

背景:与普通成年人相比,青少年时期吸食大麻的情况非常普遍。除了大麻使用与焦虑症之间的高度共存性之外,早期证据还表明,大麻可能先于焦虑症的发生。此外,青春期是神经生物学和心理过程的重要发育期,使这些人更容易受到大麻的影响:本系统综述和荟萃分析研究了青少年使用大麻与后续焦虑结果(即焦虑症和/或症状)之间的前瞻性关联:按照PRISMA指南,对数据库建立至2022年9月期间发表的文章数据进行了系统综述和荟萃分析:结果:确定了六项纵向研究进行定量分析,同时确定了十二项非重叠纵向研究进行定性审查(总人数=18;33380 名受试者)。元分析结果表明,青少年吸食大麻与随后出现焦虑症之间存在关联(Odds Ratio = 2.14,95% CI:1.37-3.36,p 讨论):总之,目前的证据表明,青少年吸食大麻与日后的焦虑症状和焦虑症之间存在前瞻性关联。这些发现强调了改进研究方法、考虑性别差异和控制混杂因素的重要性,以及实施教育计划和制定临床干预措施以应对青少年吸食大麻带来的心理健康风险的重要性。
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Cannabis use in adolescents and anxiety symptoms and disorders: a systematic review and meta-analysis.

Background: The use of cannabis is highly prevalent during adolescence compared to the general adult population. In addition to the high comorbidity between cannabis use and anxiety disorders, early evidence suggests that cannabis may precede the development of anxiety. Moreover, adolescence represents a major developmental period for both neurobiological and psychological processes, placing these individuals at a heightened vulnerability to the influence of cannabis.Objectives: This systematic review and meta-analysis examined the prospective associations between adolescent cannabis use and subsequent anxiety outcomes (i.e. anxiety disorders and/or symptoms).Methods: Following PRISMA guidelines, a systematic review and meta-analysis were conducted encompassing data from articles published between database inception and September 2022.Results: Six longitudinal studies were identified for quantitative analysis, while twelve non-overlapping longitudinal studies were identified for qualitative review (total N = 18; 33380 subjects). Meta-analytical findings supported an association between adolescent cannabis use and the development of a subsequent anxiety disorder (Odds Ratio = 2.14, 95% CI: 1.37-3.36, p < .01). These findings were consistent with our qualitative synthesis where nine of the twelve longitudinal studies observed a significant relationship between adolescent cannabis use and exacerbation of anxiety symptoms later in life, irrespective of an anxiety disorder diagnosis.Discussion: In summary, the current evidence suggests a prospective association between adolescent cannabis use and later anxiety symptoms and disorders. These findings underscore the importance of refining research methodologies, considering sex-based differences and controlling for confounding factors, as well as implementing educational initiatives and developing clinical interventions to address the mental health risks associated with cannabis use among adolescents.

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来源期刊
CiteScore
4.70
自引率
3.70%
发文量
68
期刊介绍: The American Journal of Drug and Alcohol Abuse (AJDAA) is an international journal published six times per year and provides an important and stimulating venue for the exchange of ideas between the researchers working in diverse areas, including public policy, epidemiology, neurobiology, and the treatment of addictive disorders. AJDAA includes a wide range of translational research, covering preclinical and clinical aspects of the field. AJDAA covers these topics with focused data presentations and authoritative reviews of timely developments in our field. Manuscripts exploring addictions other than substance use disorders are encouraged. Reviews and Perspectives of emerging fields are given priority consideration. Areas of particular interest include: public health policy; novel research methodologies; human and animal pharmacology; human translational studies, including neuroimaging; pharmacological and behavioral treatments; new modalities of care; molecular and family genetic studies; medicinal use of substances traditionally considered substances of abuse.
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