米尔贝霉素能否改变抗真菌药物耐药性真菌病的现状?

IF 2.7 3区 医学 Q3 INFECTIOUS DISEASES Medical mycology Pub Date : 2024-01-27 DOI:10.1093/mmy/myae003
Rui Kano, Tsuyoshi Yamada, Takashi Tamura, Koichi Makimura
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引用次数: 0

摘要

米尔贝霉素肟是一种大环内酯,对动物线虫感染具有广谱活性。众所周知,它们能阻止药物外流,从而增加真菌对唑类的敏感性。我们研究了米尔贝霉素对真菌(烟曲霉、白色念珠菌、白色念珠菌、新型隐球菌和红毛癣菌)唑类药物敏感性的影响。为了筛选唑类药物敏感性的变化,在含有 1 μg/ml 米尔贝霉素的培养基上对真菌生长进行了测试。结果表明,米尔贝霉素增加了白僵菌、球孢霉、新变形真菌和红曲霉耐唑菌株对唑类的敏感性。因此,米尔贝霉素可能对抗真菌耐药菌株有用。
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Is milbemycin a game changer against antifungal drug-resistant mycoses?

Milbemycin oximes are macrocyclic lactones that have a broad spectrum of activity against nematode infection in animals. They are known to block drug efflux, which increases the susceptibility of fungi to azoles. We investigated the effects of milbemycin on the azole susceptibility of fungi (Aspergillus fumigatus, Candida albicans, C. auris, Cryptococcus neoformans, and Trichophyton rubrum). To screen for changes in azole susceptibility, fungal growth was tested on a culture medium containing 1 μg/ml milbemycin. The results showed that milbemycin increased the azole susceptibility of azole-resistant strains of C. albicans, C. auris, C. neoformans, and T. rubrum. Thus, milbemycin might be useful against antifungal drug-resistant strains.

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来源期刊
Medical mycology
Medical mycology 医学-兽医学
CiteScore
5.70
自引率
3.40%
发文量
632
审稿时长
12 months
期刊介绍: Medical Mycology is a peer-reviewed international journal that focuses on original and innovative basic and applied studies, as well as learned reviews on all aspects of medical, veterinary and environmental mycology as related to disease. The objective is to present the highest quality scientific reports from throughout the world on divergent topics. These topics include the phylogeny of fungal pathogens, epidemiology and public health mycology themes, new approaches in the diagnosis and treatment of mycoses including clinical trials and guidelines, pharmacology and antifungal susceptibilities, changes in taxonomy, description of new or unusual fungi associated with human or animal disease, immunology of fungal infections, vaccinology for prevention of fungal infections, pathogenesis and virulence, and the molecular biology of pathogenic fungi in vitro and in vivo, including genomics, transcriptomics, metabolomics, and proteomics. Case reports are no longer accepted. In addition, studies of natural products showing inhibitory activity against pathogenic fungi are not accepted without chemical characterization and identification of the compounds responsible for the inhibitory activity.
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