合成 N1-咖啡酰-N10-二氢咖啡酰开胃苷（司可坦胺 D）

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2024-01-26 DOI:10.2174/0115701786282079231229050431

Jingwen Ji, Zafar Iqbal, Liuyan Li, Jian Sun, Pengjuan Zhou, Lijuan Zhai, Lili He, Dong Tang, Jinbo Ji, Haikang Yang, Zhixiang Yang

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引用次数: 0

摘要

:N1-咖啡酰-N10-二氢咖啡酰基过氨酸（司可坦胺 D）是一种从多种植物中分离出来的过氨酸生物碱，是一种具有药用价值的天然产品。最近的研究指出了这种化合物对健康的多种益处。然而，文献中仍未描述其合成过程。我们报告了采用两种不同的方案合成这种化合物的情况，这两种方案包括多个步骤，总体收率极高，分别为 57% 和 81%。这两种合成方案使用的是市面上较便宜的起始原料，有助于大规模生产司各脱胺 D。

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Synthesis of N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D)

: N1-caffeoyl-N10-dihydrocaffeoylspermidine (Scotanamine D), a spermidine alkaloid isolated from various plants, is a medicinally valuable natural product. Recent studies have pointed out several health benefits of this compound. However, its synthetic procedures are still not described in the literature. We report the synthesis of this compound following two different schemes comprising multiple steps with excellent overall yields, which are 57% and 81%, respectively. These two synthetic schemes, which use commercially available and cheaper starting materials, can facilitate the large-scale manufacturing of Scotanamine D.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.