lixia Li, Qi Zhang, Ce Bian, Wei Wei, Wenxuan Sun, Lu Ji, Hande Wang, Chuan Zhou, Ke Wang, Dangsheng Gong, Dongmao Yan
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Two-step Continuous-Flow Synthesis of 1,2-dimethyl-3-methylsulfanylbenzene via Diazotization and Methanethiolation
: 1,2-Dimethyl-3-methylsulfanylbenzene is the key intermediate of topramezone. This work designed a two-step continuous-flow device to synthesize 1,2-dimethyl-3-methylsulfanylbenzene via diazotization and methanethiolation. The results showed that compared with the batch process, the continuous-flow method greatly shortened the residence time to 1 minute, avoided the accumulation of large amounts of diazonium salts to reduce decomposition and increased the product yield to 91.7%. At the same time, the continuous-flow process improved the safety and efficiency of the reactions, saved reaction time and had good prospects for industrial application.
期刊介绍：
Current Organic Chemistry aims to provide in-depth/mini reviews on the current progress in various fields related to organic chemistry including bioorganic chemistry, organo-metallic chemistry, asymmetric synthesis, heterocyclic chemistry, natural product chemistry, catalytic and green chemistry, suitable aspects of medicinal chemistry and polymer chemistry, as well as analytical methods in organic chemistry. The frontier reviews provide the current state of knowledge in these fields and are written by chosen experts who are internationally known for their eminent research contributions. The Journal also accepts high quality research papers focusing on hot topics, highlights and letters besides thematic issues in these fields. Current Organic Chemistry should prove to be of great interest to organic chemists in academia and industry, who wish to keep abreast with recent developments in key fields of organic chemistry.
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