天然生物碱和抗癌作用机制：综述

Q2 Pharmacology, Toxicology and Pharmaceutics Current Bioactive Compounds Pub Date : 2024-01-23 DOI:10.2174/0115734072276134231130170407

Prem Mishra, Niranjan Kaushik, Rakhi Mishra, Sameeksha Koul, Sakshi Sagar

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引用次数: 0

摘要

癌症是一个全球性的公共卫生问题。癌症治疗一直受到多种药物耐药性问题的阻碍，而耐药性是导致全球死亡的主要原因之一。因此，几十年来，人们一直在研究和开发利用天然药物来预防和治疗癌症。生物碱是源自植物的次级代谢产物，对多种癌症具有抗增殖和抗癌作用。喜树碱和乙烯嘧啶这两种从生物碱中提取的抗癌药物在过去已经得到了充分的开发。生物碱作为一种药物先导化合物，来源于天然产物，具有可被宿主利用的优势，因此适合进一步开发。本综述探讨了多种天然生物碱的抗癌潜力及其抗癌作用的机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Natural Alkaloids and Mechanisms for Anti-cancer Action: A Review

Cancer is a global public health issue. Cancer therapy has been hampered by the issue of multidrug resistance, which is one of the leading causes of death worldwide. As a result, the use of natural derived drugs for cancer prevention and therapy has been researched and developed for decades. Alkaloids are plant-derived secondary metabolites that have antiproliferative and anticancer effects on several forms of cancer. Camptothecin and vinblastine, two anticancer medicines derived from alkaloids, have been adequately developed in the past. Alkaloids, a drug lead compounds, derived from natural products, have the advantage of being used by the host, making them suitable for further exploitation. The current review looks at the anticancer potential of numerous naturally occurring alkaloids, as well as the mechanism behind their anticancer effect.

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.