Iacopo Megna, S. Penpa, A. Cassinari, Christian Leli, Andrea Rocchetti, A. Roveta, Marta Betti, A. Maconi
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引用次数: 0
摘要
目的:本研究旨在比较意大利亚历山德里亚综合医院住院患者中严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)肺炎和肺炎链球菌肺炎的临床、病理和实验室特征及结果。材料和方法:通过胸部 X 光和/或胸部计算机断层扫描(CT)对肺炎进行放射学诊断;通过鼻咽拭子逆转录酶聚合酶链反应(RT-PCR)对 SARS-CoV-2 感染进行微生物学诊断;通过尿液抗原检测呈阳性和/或从呼吸道和/或血液培养物中分离出肺炎链球菌对肺炎链球菌肺炎进行病原学诊断。结果:共纳入 222 例患者,其中 171 例为 SARS-CoV-2 肺炎患者,51 例为肺炎双球菌肺炎患者。SARS-CoV-2 组最常接受抗病毒药物治疗:139/171(81.3%) vs 1/51(2.1%);p<0.001;他们通常需要氧疗:142/171(83%) vs 27/51(56.3%);p<0.001;以及无创机械通气:59/171(34.5%)对 7/51(14.6%);P=0.004。SARS-CoV-2 肺炎患者的死亡率较高:46/171(26.9%)高于肺炎球菌肺炎患者:5/51(9.8%);P=0.011。结论:研究结果显示,SARS-CoV-2 和肺炎球菌引起的肺炎在男性中的发病率高于女性。此外,与肺炎双球菌相比,SARS-CoV-2 肺炎患者并发症和死亡的风险更高。
SARS-CoV-2 vs Streptococcus pneumoniae: a comparison of clinical features, laboratory findings, and clinical outcomes in patients hospitalized at Alessandria’s General Hospital
Aims: the aim of the present study was to compare the clinical, anamnestic, and laboratory features and outcomes of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pneumonia and pneumonia caused by Streptococcus pneumoniae in hospitalized patients at the General Hospital of Alessandria, Italy. Materials and Methods: radiological diagnosis of pneumonia by chest X-ray and/or chest Computed Tomography (CT); microbiological diagnosis of SARS-CoV-2 infection by nasopharyngeal swab Reverse Transcriptase - Polymerase Chain Reaction (RT-PCR), etiological diagnosis of S. pneumoniae pneumonia by positive urinary antigen detection and/or isolation of S. pneumoniae from respiratory and/or blood cultures. Results: 222 patients were included, 171 with SARS-CoV-2 pneumonia and 51 with S. pneumoniae. SARS-CoV-2 group most frequently treated with antiviral drugs: 139/171 (81.3%) vs 1/51 (2.1%); p<0.001; they often needed oxygen therapy: 142/171 (83%) vs 27/51 (56.3%); p<0,001; and non-invasive mechanical ventilation: 59/171 (34.5%) vs 7/51 (14.6%); p=0.004. Mortality was higher in SARS-CoV-2 pneumonia patients: 46/171 (26.9%) than in pneumococcal pneumonia patients 5/51 (9.8%); p=0.011. Conclusions: the study showed the increased prevalence of pneumonia caused by SARS-CoV-2 and S. pneumoniae in males than in females. Moreover, patients with SARS-CoV-2 pneumonia represent higher risk group for complications and death than S. pneumoniae.