缺血缺氧时的费舍尔低聚肽比值：补充苏醒素和褪黑素的预防性修正作用

IF 4.7 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-01-17 DOI:10.2144/fsoa-2023-0117

Mai O Kadry, H. Ali

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引用次数: 0

摘要

目的：缺血缺氧的基本病理生理学是氧耗竭。费舍尔比值对监测缺氧强度至关重要。方法：本研究强调了苏醒素（QRC）和/或褪黑素（MLN）对亚硝酸钠（SN）脑缺氧的预防作用。研究结果预防性治疗前，先用亚硝酸钠（60 毫克/千克，S.C.）诱导缺氧。亚硝酸钠会降低血红蛋白（Hb），升高 HIF-α、HSP-70、IL-6 和 TNF-α。槐黄素和/或 MLN 恢复了已改善的炎症生物标志物，调节了去甲肾上腺素、多巴胺、5-羟色胺和γ-氨基丁酸（GABA）。同样，单细胞凝胶电泳（SCGE 或 COMET）DNA 损伤检测也证实了这一发现。结论通过舒泊汀和 MLN 治疗是改善亚硝酸钠诱导的脑损伤的最有效疗法。

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Fischer's oligopeptide ratio in ischemic hypoxia: prophylactic amendment of sophoretin and melatonin supplementation

Aim: The fundamental pathophysiology of ischemic-hypoxia is oxygen depletion. Fischer's ratio is essential for monitoring hypoxia intensity. Methods: the current study highlighted the prophylactic role of sophoretin (QRC) and/or melatonin (MLN) versus sodium nitrite (SN) brain hypoxia. Results: Prophylactic treatment with sophoretin and MLN, was preceded with hypoxia-induction via sodium nitrite (60 mg/kg, S.C.). SN decreased hemoglobin (Hb), elevated HIF-α, HSP-70, IL-6 and TNF-α. Sophoretin and/or MLN restored the ameliorated inflammatory biomarkers, modulated norepinephrine, dopamine, serotonin and gamma-aminobutyric acid (GABA). Similarly, single-cell gel electrophoresis (SCGE or COMET) DNA-damage assay confirmed this finding. Conclusion: Treatment via sophoretin and MLN was the most effective therapy for improving sodium nitrite induced brain injury.

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464

期刊介绍： ACS Applied Bio Materials is an interdisciplinary journal publishing original research covering all aspects of biomaterials and biointerfaces including and beyond the traditional biosensing, biomedical and therapeutic applications. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrates knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important bio applications. The journal is specifically interested in work that addresses the relationship between structure and function and assesses the stability and degradation of materials under relevant environmental and biological conditions.