肺部非典型大细胞神经内分泌癌病例中的误导性喘息--致命品种

Jeevanandham Anandan, Zeenathalam Nadaf, Sneha Leo
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摘要

神经内分泌肿瘤是由内分泌和神经系统细胞产生的肿瘤,这些细胞含有特殊的分泌颗粒,内含生物胺和多肽激素。其中一种常见于肺部的肿瘤是大细胞神经内分泌癌。这些神经内分泌恶性肿瘤的复制潜力非常快,患者通常会出现转移性疾病。我们描述了一例因夜间喘息而被误诊为支气管哮喘的 29 岁男性病例,最后发现是伴有支气管内膜阻塞的 LCNEC。这种病变通常位于周围,多发生在吸烟的老年男性的上肺区。但由于支气管内阻塞,他有一个伴有右肺下叶塌陷的肺门肿块。因此,仔细检查喘息,无论是单侧还是双侧、单音还是多音、随机还是固定、吸气还是呼气或双相,都有助于早期发现支气管内病变。
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Misleading wheeze in a case of atypical large cell neuroendocrine carcinoma of lung - A deadly variety
Neuroendocrine tumors are neoplasms arising from cells of endocrine and nervous system containing special secretory granules with biogenic amines and polypeptide hormones. One of the varieties that occurs commonly in the lung is large cell neuro endocrine carcinoma. The replicative potential of these neuroendocrine malignancies is so rapid that the patients usually present with metastatic disease. We describe a case of 29-year-old-male presented with nocturnal wheeze which led on to a misdiagnosis of bronchial asthma and finally found to be LCNEC with endobronchial obstruction. They are usually peripherally located lesions, mostly in the upper lung zones of an elderly male smoker. But he had a hilar mass with right lower lobe collapse due to endobronchial obstruction. Hence careful examination of wheeze whether unilateral or bilateral, monophonic or polyphonic, random or fixed, inspiratory or expiratory or biphasic may help in early identification of the endobronchial lesions.
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