V. I. Shcherbakov, O. Obukhova, T. Ryabichenko, G. Skosyreva, O. Gorbenko, T. G. Kosyanova
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引用次数: 0
摘要
该研究的目的是调查在慢性肾盂肾炎未加重的背景下,妊娠期调节性和促炎症分子的水平。采用 ELISA 方法测定妊娠期为 36-40 周的孕妇血清中 IL-17A、单核细胞趋化蛋白-1(MCP-1)、血管内皮生长因子(VEGF)和双链 DNA IgG 自身抗体(AAT to nDNA)的浓度。结果表明,与正常妊娠相比,在慢性肾盂肾炎未加重的背景下,妊娠三个月时,MHP-1 和 IL-17A 水平升高,血管内皮生长因子含量降低,而 AAT 对 nDNA 的浓度变化不大。促炎细胞因子IL-17A的增加和血管内皮生长因子含量的降低会导致胎儿宫内生长迟缓,这是由于胎盘中的氨基酸转运体受到了抑制。在慢性肾盂肾炎未加重的背景下妊娠,IL17A、MСP-1和VEGF水平的变化会对妊娠过程产生重大影响。
Study of various groups of regulatory molecules during pregnancy against the background of chronic pyelonephritis
The presence of infectious inflammatory process in a pregnant woman can lead to a disorder in the “mother – placenta – fetus” system.Aim of the study was to investigate the level of regulatory and pro-inflammatory molecules in pregnancy occurring against the background of chronic pyelonephritis without exacerbation.Material and methods. The concentration of IL-17A, monocytic chemotactic protein-1 (MCP-1), vascular endothelial growth factor (VEGF), and IgG autoantibodies to double-stranded DNA (AAT to nDNA) was determined in the blood serum of pregnant women with a gestation period of 36–40 weeks using ELISA.Results. It has been shown that in the third trimester of pregnancy occurring against the background of chronic pyelonephritis without exacerbation, compared with a normal pregnancy, the level of MHP-1 and IL-17A increases, the content of VEGF decreases, and the concentration of AAT to nDNA does not change significantly. An increase in the proinflammatory cytokine IL17A and a decrease in VEGF level can lead to intrauterine fetal growth retardation due to inhibition of amino acid transporters in the placenta.Conclusions. In pregnancy occurring against the background of chronic pyelonephritis without exacerbation, a change in the level of IL17A, MСP-1, VEGF can have a significant impact on the course of pregnancy.