HIV Serodiscordance: Diagnosis Problem in the Douentza Heath District

Summary: Human immunodeficiency virus (HIV) is an infection that attacks the body's immune system. The most advanced stage of HIV infection is acquired immunodeficiency syndrome (AIDS). HIV is spread through the body fluids of an infected person, including blood, breast milk, semen, and vaginal fluids. Observation: These were 2 patients who had been consulted for a transfusion during which routine screening was carried out. Faced with divergent results, the hypothesis of a serodiscordance was raised. Series of tests carried out came back sometimes Negative and sometimes positive. It was the result of the PCR which made it possible to conclude that it was negative for HIV infection. These results had an impact on the psychological state of donors and could contribute to raising questions on the quality, specificity and/or sensitivity of current tests? On the interaction of one or more viral markers of another unknown viral pathology? And on the other hand on a possible genetic predisposition of these blood donors? Conclusion: HIV is a preventable disease. Awareness campaigns and promotion of early detection are effective ways to reduce transmission.