外显子发生:了解机遇、影响、关切和前进方向

O. Okesanya, A. J. Gacutno‐Evardone, Abideen A. Olaniyi, H. K. Hassan, K. J. A. Gacutno, N. O. Olaleke, R. Adesola, Jose J. Lasala, E. Manirambona, D. Lucero‐Prisno
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引用次数: 0

摘要

外胚层发育是在人工环境中培养生物的做法,其应用范围从改善早产儿的预后到治疗生育问题不等。它于2017年亮相,为部分和完全异位生殖提供了可能,同时通过生物袋等概念维持胎羔的生长。利用生物袋人工子宫,完全异位妊娠是指从胚胎萌发阶段到完全妊娠,将妇女的妊娠限制在人工子宫中;而部分异位妊娠是指利用生物袋人工子宫继续宫外妊娠。异位妊娠可能有其优点,但也有人担心它会影响儿童的社会和心理发展。它可以有利于生儿育女、新生儿护理、胎儿治疗、母婴纠纷、社会发展、降低健康风险、改变文化规范,同时促进生殖公平。由于可能存在风险,在实施异位生殖之前,需要对人体进行严格的研究。本文试图对其潜在优势及其技术、伦理和监管要素进行深入研究,供社会讨论和审议。
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Ectogenesis: understanding opportunities, implications, concerns, and ways forward
Ectogenesis is the practice of developing organisms in artificial settings, with applications that range from improving the outcomes of preterm babies to treating fertility issues. It was unveiled in 2017 and provides possibilities for both partial and full ectogenesis while sustaining fetal lambs with concepts like the biobag. Utilizing biobag artificial uteri, complete ectogenesis is the confinement of a woman’s pregnancy in an artificial womb from the inception of the embryonic stage to full gestation; while partial ectogenesis is the utilization of a biobag artificial uterus to continue gestation ex-utero. Ectogenesis may have advantages, but there are concerns about how it will affect children’s social and psychological development. It can benefit biological parenthood, newborn care, fetal therapy, maternal-fetal disputes, societal growth, reduce health risks, and alter cultural norms while promoting reproductive equity. Due to possible risks, rigorous research on human subjects is required before ectogenesis may be implemented. The paper seeks to provide a thorough study for society’s conversation and deliberation, examining its potential advantages as well as its technical, ethical, and regulatory elements.
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