子宫颈绒毛腺癌的 PD-L1 表达和席尔瓦侵袭模式

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-07-01 Epub Date: 2024-01-31 DOI:10.1097/PGP.0000000000001006
Anna K Dietl, Matthias W Beckmann, Frederik A Stuebs, Paul Gass, Julius Emons, Arndt Hartmann, Ramona Erber
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引用次数: 0

摘要

子宫颈绒毛腺癌(VGA)是年轻女性宫颈内膜腺癌的一种罕见亚型。2007 年至 2020 年间,我们对所有患有宫颈内膜腺癌的女性进行了回顾性研究,以发现 VGA 患者。其中包括八名确诊为纯VGA的患者。初次确诊时的平均年龄为 36.3 岁(24-46 岁不等)。手术治疗后,对患者进行了长达 59 个月(16-150 个月)的随访。迄今为止,所有患者均健在,且无疾病迹象。未发现淋巴结受累或淋巴管侵犯。此外,我们还对样本进行了检查,重点是形态学侵袭模式(Silva)、基质肿瘤浸润淋巴细胞(sTILs)和免疫组化程序性死亡配体-1(PD-L1)表达。使用综合阳性评分(临界值≥1%),7/8的VGA观察到PD-L1表达;使用肿瘤比例评分(临界值≥1%),1/8的VGA观察到PD-L1表达;使用免疫细胞评分(临界值≥1%),7/8的VGA观察到PD-L1表达。综合阳性评分和免疫细胞,7/8 的 B 型和 C 型肿瘤有 PD-L1 表达,其中破坏型肿瘤的 PD-L1 表达明显更高(P<0.05)。
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PD-L1 Expression and Silva Invasion Pattern in Villoglandular Adenocarcinoma of the Uterine Cervix.

Villoglandular adenocarcinoma (VGA) of the uterine cervix is a rare subtype of endocervical adenocarcinoma in young women. Between 2007 and 2020, all women with endocervical adenocarcinoma were retrospectively reviewed to find patients with VGA. Eight patients in whom pure VGA had been diagnosed were included. The mean age at initial diagnosis was 36.3 years (range 24-46). After surgical treatment, patients were followed up for 59 months (range 16-150). To date, all patients are alive with no evidence of disease. Neither lymph node involvement nor lymphovascular invasion was found. Furthermore, we examined the samples with a focus on morphological invasion pattern (Silva), stromal tumor-infiltrating lymphocytes (sTILs), and immunohistochemical programmed death ligand-1 (PD-L1) expression. PD-L1 expression was observed in 7/8 using the combined positive score (cutoff≥1%), 1/8 of VGAs using the tumor proportion score (cutoff≥1%), and 7/8 using the immune cell (cutoff≥1%). Using combined positive score and immune cell, PD-L1 expression was seen in 7/8 of pattern B and C tumors, with significantly higher expression in tumors with destructive-type patterns ( P <0.05, A vs. B+C). Using tumor proportion score, no significant difference in PD-L1 expression was seen between VGAs with different invasion patterns. VGAs demonstrated twice higher sTILs in tumors with destructive-type invasion patterns. Our observations suggest that PD-L1 expression, tumor invasion patterns, and sTILs do not correlate with the excellent prognosis of pure VGA.

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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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