嗜极细胞工厂在工业生物技术中的应用

IF 3.4 3区生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Enzyme and Microbial Technology Pub Date : 2024-01-30 DOI:10.1016/j.enzmictec.2024.110407

Yuzhou Wang , Jinyi Qian , Tianqiong Shi , Yuetong Wang , Qiang Ding , Chao Ye

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引用次数: 0

摘要

由于生活条件极端恶劣，嗜极微生物在形态、结构、生理、生化、分子进化机制等方面都具有独特的特征。与传统微生物相比，嗜极微生物在恶劣条件下具有更强的生长和合成能力，可以实现无灭菌发酵过程，从而在低成本生产中发挥更好的性能。近年来，随着分子生物学、合成生物学和发酵技术的发展和优化，嗜极微生物的鉴定和筛选技术有了很大提高。在这篇综述中，我们总结了嗜极端微生物的鉴定和筛选技术，并回顾了近年来它们在工业生物技术中的应用。此外，本综述收集的事实和观点表明，基于工程嗜极菌的下一代工业生物技术（NGIBs）有望简化生物固化过程，建立开放、非灭菌的连续发酵生产系统，并利用低成本基质，使 NGIBs 成为具有吸引力和成本效益的生物加工技术，从而实现可持续生产。

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Application of extremophile cell factories in industrial biotechnology

Due to the extreme living conditions, extremophiles have unique characteristics in morphology, structure, physiology, biochemistry, molecular evolution mechanism and so on. Extremophiles have superior growth and synthesis capabilities under harsh conditions compared to conventional microorganisms, allowing for unsterilized fermentation processes and thus better performance in low-cost production. In recent years, due to the development and optimization of molecular biology, synthetic biology and fermentation technology, the identification and screening technology of extremophiles has been greatly improved. In this review, we summarize techniques for the identification and screening of extremophiles and review their applications in industrial biotechnology in recent years. In addition, the facts and perspectives gathered in this review suggest that next-generation industrial biotechnology (NGIBs) based on engineered extremophiles holds the promise of simplifying biofuturing processes, establishing open, non-sterilized continuous fermentation production systems, and utilizing low-cost substrates to make NGIBs attractive and cost-effective bioprocessing technologies for sustainable manufacturing.

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来源期刊

Enzyme and Microbial Technology 生物-生物工程与应用微生物

CiteScore

7.60

自引率

5.90%

发文量

142

审稿时长

38 days

期刊介绍： Enzyme and Microbial Technology is an international, peer-reviewed journal publishing original research and reviews, of biotechnological significance and novelty, on basic and applied aspects of the science and technology of processes involving the use of enzymes, micro-organisms, animal cells and plant cells. We especially encourage submissions on: Biocatalysis and the use of Directed Evolution in Synthetic Biology and Biotechnology Biotechnological Production of New Bioactive Molecules, Biomaterials, Biopharmaceuticals, and Biofuels New Imaging Techniques and Biosensors, especially as applicable to Healthcare and Systems Biology New Biotechnological Approaches in Genomics, Proteomics and Metabolomics Metabolic Engineering, Biomolecular Engineering and Nanobiotechnology Manuscripts which report isolation, purification, immobilization or utilization of organisms or enzymes which are already well-described in the literature are not suitable for publication in EMT, unless their primary purpose is to report significant new findings or approaches which are of broad biotechnological importance. Similarly, manuscripts which report optimization studies on well-established processes are inappropriate. EMT does not accept papers dealing with mathematical modeling unless they report significant, new experimental data.