Obesity and Depression. Some Neurochemical and Molecular Links

Abstract

In recent decades, the fast-paced nature of life and increased social and professional competition have led to a notable rise in depression rates. This condition profoundly impacts individuals’ quality of life and overall well-being. Simultaneously, the characteristics of modern society, along with numerous environmental stressors and dietary habits, have contributed to the escalating prevalence of obesity and other metabolic disorders. Obesity and depression, two pressing issues in modern medicine, may initially appear unrelated as one is a metabolic condition and the other a mental health disorder. However, they are intricately intertwined: evidence suggests that individuals with obesity are more susceptible to experiencing depression, and vice versa. This review highlights the link between obesity and depression on a molecular and neurochemical level.