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引用次数: 0
摘要
摘要 血啡肽是血红蛋白β链依次裂解过程中释放的一系列内源性非典型阿片肽。脑啡肽广泛分布于机体内，与多种疾病的病理生理学有关，包括糖尿病、癌症、阿尔茨海默病等。几十年前，人们就发现了这些多肽，并揭示了它们的多种治疗效果。然而，有关血啡肽的合成、代谢和治疗效果的确切分子机制尚未完全清楚。在这篇综述中，简要总结了目前有关血啡肽的知识，重点是它们的生物活性以及血啡肽作用机制所涉及的 Ca2+/CaM/CN 信号通路。亚美尼亚生物化学研究所（Institute of Biochemistry）对这些肽进行了深入研究，本综述对基本结果进行了全面讨论。
Hemorphins are a family of endogenous atypical opioid peptides released during the sequential cleavage of hemoglobin β-chain. Hemorphins are widely distributed in the organism and are implicated in pathophysiology of several diseases, including diabetes, cancer, Alzheimer disease and others. These peptides were identified several decades ago and their diverse therapeutic effects have been revealed. However, the exact molecular mechanisms involved in synthesis, metabolism and therapeutic effect of hemorphins are not fully understood. In this review, the current knowledge of hemorphins, focusing on their biological activity and Ca2+/CaM/CN-signaling pathway, involved in mechanisms of hemophins action is briefly summarized. These peptides have been intensively investigated at the Institute of Biochemistry (Armenia), and fundamental results are thoroughly discussed in this review.
期刊介绍：
Neurochemical Journal (Neirokhimiya) provides a source for the communication of the latest findings in all areas of contemporary neurochemistry and other fields of relevance (including molecular biology, biochemistry, physiology, neuroimmunology, pharmacology) in an afford to expand our understanding of the functions of the nervous system. The journal presents papers on functional neurochemistry, nervous system receptors, neurotransmitters, myelin, chromaffin granules and other components of the nervous system, as well as neurophysiological and clinical aspects, behavioral reactions, etc. Relevant topics include structure and function of the nervous system proteins, neuropeptides, nucleic acids, nucleotides, lipids, and other biologically active components.
The journal is devoted to the rapid publication of regular papers containing the results of original research, reviews highlighting major developments in neurochemistry, short communications, new experimental studies that use neurochemical methodology, descriptions of new methods of value for neurochemistry, theoretical material suggesting novel principles and approaches to neurochemical problems, presentations of new hypotheses and significant findings, discussions, chronicles of congresses, meetings, and conferences with short presentations of the most sensational and timely reports, information on the activity of the Russian and International Neurochemical Societies, as well as advertisements of reagents and equipment.
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