通过像素组装实现带微流体功能模块的可重编磁性软致动器

IF 4.1 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY ACS Chemical Neuroscience Pub Date : 2024-01-31 DOI:10.1002/smll.202310009
Xiaoyu Zhao, Hongyi Yao, Yaoyi Lv, Zhixian Chen, Lina Dong, Jiajun Huang, Shengli Mi
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引用次数: 0

摘要

磁性软致动器和机器人因其反应速度快、可编程性和生物兼容性而在生物医学应用中备受关注。尽管最近取得了一些进展,但磁性致动器的制造工艺及其磁化曲线的重新编程方法仍面临挑战。本文报告了一种基于硅胶基底上可重复使用的磁像素的排列和分布的简便制造策略,可制造出具有可定制架构、任意磁化曲线和集成微流体技术的各种磁性致动器。这种方法可以实现具有良好变形能力和可编程能力的复杂配置,以及在磁致动时涉及抓握、游泳和蠕动的仿生物运动。此外,还集成了微流体功能模块,用于开关阀门控制、曲率调节、流体混合、动态微流体结构和液体输送机器人等多种用途。建议的方法满足了低成本、快速和简化磁性致动器制备的要求,因为它无需在磁化过程中维持预定义的变形,也无需使用激光加热或其他刺激来重新编程磁化曲线。因此,通过像素组装技术制造的磁性致动器在微流体和生物医学应用领域具有广阔的前景。
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Reprogrammable Magnetic Soft Actuators with Microfluidic Functional Modules via Pixel-Assembly

Magnetic soft actuators and robots have attracted considerable attention in biomedical applications due to their speedy response, programmability, and biocompatibility. Despite recent advancements, the fabrication process of magnetic actuators and the reprogramming approach of their magnetization profiles continue to pose challenges. Here, a facile fabrication strategy is reported based on arrangements and distributions of reusable magnetic pixels on silicone substrates, allowing for various magnetic actuators with customizable architectures, arbitrary magnetization profiles, and integration of microfluidic technology. This approach enables intricate configurations with decent deformability and programmability, as well as biomimetic movements involving grasping, swimming, and wriggling in response to magnetic actuation. Moreover, microfluidic functional modules are integrated for various purposes, such as on/off valve control, curvature adjustment, fluid mixing, dynamic microfluidic architecture, and liquid delivery robot. The proposed method fulfills the requirements of low-cost, rapid, and simplified preparation of magnetic actuators, since it eliminates the need to sustain pre-defined deformations during the magnetization process or to employ laser heating or other stimulation for reprogramming the magnetization profile. Consequently, it is envisioned that magnetic actuators fabricated via pixel-assembly will have broad prospects in microfluidics and biomedical applications.

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来源期刊
ACS Chemical Neuroscience
ACS Chemical Neuroscience BIOCHEMISTRY & MOLECULAR BIOLOGY-CHEMISTRY, MEDICINAL
CiteScore
9.20
自引率
4.00%
发文量
323
审稿时长
1 months
期刊介绍: ACS Chemical Neuroscience publishes high-quality research articles and reviews that showcase chemical, quantitative biological, biophysical and bioengineering approaches to the understanding of the nervous system and to the development of new treatments for neurological disorders. Research in the journal focuses on aspects of chemical neurobiology and bio-neurochemistry such as the following: Neurotransmitters and receptors Neuropharmaceuticals and therapeutics Neural development—Plasticity, and degeneration Chemical, physical, and computational methods in neuroscience Neuronal diseases—basis, detection, and treatment Mechanism of aging, learning, memory and behavior Pain and sensory processing Neurotoxins Neuroscience-inspired bioengineering Development of methods in chemical neurobiology Neuroimaging agents and technologies Animal models for central nervous system diseases Behavioral research
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