人类线粒体 tRNA 代谢的病理生理学

Trends in Endocrinology & Metabolism Pub Date : 2024-02-01 DOI:10.1016/j.tem.2024.01.002

Jian-Hui Zhang, Gilbert Eriani, Xiao-Long Zhou

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引用次数: 0

摘要

线粒体在细胞活动中发挥着多种关键作用。其中，线粒体翻译在调节线粒体和细胞平衡中起着关键作用。在本论坛文章中，我们将讨论人类线粒体 tRNA 代谢，并强调其与氨基酸-tRNA 合成酶、tRNA 和 tRNA 修饰酶突变导致的各种线粒体疾病之间的密切联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Pathophysiology of human mitochondrial tRNA metabolism

Mitochondria play multiple critical roles in cellular activity. In particular, mitochondrial translation is pivotal in the regulation of mitochondrial and cellular homeostasis. In this forum article, we discuss human mitochondrial tRNA metabolism and highlight its tight connection with various mitochondrial diseases caused by mutations in aminoacyl-tRNA synthetases, tRNAs, and tRNA-modifying enzymes.

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Trends in Endocrinology & Metabolism

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