对位取代的 2-羟甲基哌嗪的温和高效合成....

IF 0.7 4区化学 Q4 CHEMISTRY, ORGANIC Letters in Organic Chemistry Pub Date : 2024-02-02 DOI:10.2174/0115701786283816240123103232

Zijian Liang, Liyuan Guo, Qian Li, Chunyan Liu, Chao Liu, Shi Wu

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引用次数: 0

摘要

在此，我们提出了一种温和有效的合成方法，利用丝氨酸甲酯和具有不同大小残基的 L-氨基酸制备对位取代的 2-羟甲基哌嗪。该合成路线具有多个优点，包括反应条件温和、试剂易得、无残余物组成以及具有克级合成潜力。值得注意的是，在我们的实验中，化合物（4g）表现出了极高的产量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Mild and efficient synthesis of para-substituted 2-hydroxymethyl piperazine....

Herein, we present a mild and effective synthetic method for preparing para-substituted 2-hydroxymethyl piperazine from serine methyl ester and L-amino acids with residues of different sizes. This synthetic route has several advantages including mild reaction conditions, availability of reagents, non-racemic composition, and the potential for gram-scale synthesis. Notably, the compound (4g) demonstrated excellent yields in our experiments.

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来源期刊

Letters in Organic Chemistry 化学-有机化学

CiteScore

1.30

自引率

12.50%

发文量

135

审稿时长

7 months

期刊介绍： Aims & Scope Letters in Organic Chemistry publishes original letters (short articles), research articles, mini-reviews and thematic issues based on mini-reviews and short articles, in all areas of organic chemistry including synthesis, bioorganic, medicinal, natural products, organometallic, supramolecular, molecular recognition and physical organic chemistry. The emphasis is to publish quality papers rapidly by taking full advantage of latest technology for both submission and review of the manuscripts. The journal is an essential reading for all organic chemists belonging to both academia and industry.