二硫化相关基因 SLC7A11 在人类癌症的抗肿瘤免疫疗法反应中的新型致癌作用

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-02-02 DOI:10.2174/0115680096277818231229105732
Borui Xu, Jiahua Liang, Liangmin Fu, Juan Lin, Jinhuan Wei
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引用次数: 0

摘要

背景:溶质运载家族 7 成员 11 蛋白质(SLC7A11)通过抑制二硫跃迁在细胞氧化还原平衡中发挥着关键作用,从而限制肿瘤的生长。然而,人们对其与预后、免疫和癌症治疗效果的相关性还不甚了解。研究方法我们利用公共数据库中的数据集对 33 种癌症类型中 SLC7A11 的表达进行了全面分析。Cox回归和生存分析等方法评估了其预后意义,而功能富集则探索了与SLC7A11相关的生物学过程。此外,还仔细研究了 SLC7A11 表达、免疫细胞浸润和免疫相关基因表达之间的关联。研究结果值得注意的是,与正常样本相比,SLC7A11在癌症样本中的表达更为明显,并且与肿瘤分级相关。SLC7A11 表达的增加与不良预后有关,尤其是在肝肝细胞癌(LIHC)中。该蛋白的表达与不同的分子和免疫亚型也有显著关系。此外,结合 SLC7A11 的表达和临床变量,还设计了一个预后提名图。SLC7A11的高水平与各种癌症的细胞生长和衰老途径以及LIHC的脂质和胆固醇代谢相关。此外,还发现了针对高 SLC7A11 的 LIHC 的潜在治疗化合物。研究人员采用实时 PCR(qPCR)和 Western 印迹技术探讨了 SLC7A11 在肿瘤组织和癌细胞系中的表达情况。结论总之,本研究强调了 SLC7A11 在预后和免疫学方面的重要性,突出了其作为 LIHC 治疗靶点的潜力。
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A Novel Oncogenic Role of Disulfidptosis-related Gene SLC7A11 in Anti--tumor Immunotherapy Response to Human Cancers
Background: The protein Solute Carrier Family 7 Member 11 (SLC7A11) plays a pivotal role in cellular redox homeostasis by suppressing disulfidptosis, which restricts tumor growth. Yet, its relevance in prognosis, immunity, and cancer treatment efficacy is not well understood. Methods: We conducted a comprehensive analysis of the expression of SLC7A11 across 33 cancer types, employing datasets from public databases. Methods, such as Cox regression and survival analyses assessed its prognostic significance, while functional enrichment explored the biological processes tied to SLC7A11. The association between SLC7A11 expression, immune cell infiltration, and immune-related gene expression was also scrutinized. Results: Notably, SLC7A11 expression was more pronounced in cancerous compared to normal samples and correlated with higher tumor grades. Increased SLC7A11 expression was linked to poor outcomes, particularly in liver hepatocellular carcinoma (LIHC). This protein's expression also showcased significant relationships with diverse molecular and immune subtypes. Additionally, a prognostic nomogram was devised, integrating SLC7A11 expression and clinical variables. High SLC7A11 levels corresponded with cell growth and senescence pathways in various cancers and with lipid and cholesterol metabolism in LIHC. Furthermore, potential therapeutic compounds for LIHC with high SLC7A11 were identified. Real-time PCR (qPCR) and Western blot were conducted to explore the expression of SLC7A11 in tumor tissues and cancer cell lines. Conclusion: In summation, this study emphasizes the prognostic and immunological importance of SLC7A11, spotlighting its potential as a therapeutic target in LIHC.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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