加巴喷丁和普瑞巴林对痴呆症躁动的影响:十名患者的病例系列

IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Revue neurologique Pub Date : 2024-06-01 DOI:10.1016/j.neurol.2023.11.006
M. Kandemir Yilmaz
{"title":"加巴喷丁和普瑞巴林对痴呆症躁动的影响:十名患者的病例系列","authors":"M. Kandemir Yilmaz","doi":"10.1016/j.neurol.2023.11.006","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":2.8000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The effect of gabapentin and pregabalin on agitation in dementia: Case series of ten patients\",\"authors\":\"M. Kandemir Yilmaz\",\"doi\":\"10.1016/j.neurol.2023.11.006\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\",\"PeriodicalId\":21321,\"journal\":{\"name\":\"Revue neurologique\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revue neurologique\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0035378724000201\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revue neurologique","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0035378724000201","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

痴呆症患者的神经行为症状很难控制。躁动可能会对患者的健康产生负面影响,并加重护理人员的负担。可以采用药物和非药物方法来减少躁动。最近,在病例报告中发现了加巴喷丁类药物的积极作用,其效果令人鼓舞,且安全性良好。本观察性研究旨在评估加巴喷丁类(加巴喷丁和普瑞巴林)对痴呆症患者躁动的影响,并记录任何不良反应。这是一项由 10 名患者(6 名女性,4 名男性)组成的观察性研究。平均年龄为 85.6 岁(范围:67-97 岁)。其中八名患者(80%)被确诊为阿尔茨海默氏症,两名患者被确诊为混合型痴呆症。所有患者均使用乙酰胆碱酯酶抑制剂和美金刚单药或联合用药。未发现实验室异常。改良外显攻击量表用于评估躁动情况。每种药物的最低剂量为睡前服用(加巴喷丁为 100 毫克,普瑞巴林为 25 毫克),然后根据疗效和不良反应逐渐增加剂量。加巴喷丁的中位剂量为 366.7 毫克/天(范围:200-600),普瑞巴林的中位剂量为 109.4 毫克/天(范围:25-300)。九名患者(90%)(三名接受加巴喷丁治疗,六名接受普瑞巴林治疗)的躁动在数天内得到控制。镇静是四名患者(40%)中唯一记录在案的不良反应。一名患者因镇静而将普瑞巴林换成了加巴喷丁,另一名患者因疗效不佳而停用了普瑞巴林。加巴喷丁类药物在老年人中的耐受性良好,即使使用较小剂量,也能对烦躁不安的患者产生良好效果。普瑞巴林对这些患者可能是一种有用的选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
The effect of gabapentin and pregabalin on agitation in dementia: Case series of ten patients
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Revue neurologique
Revue neurologique 医学-临床神经学
CiteScore
4.80
自引率
0.00%
发文量
598
审稿时长
55 days
期刊介绍: The first issue of the Revue Neurologique, featuring an original article by Jean-Martin Charcot, was published on February 28th, 1893. Six years later, the French Society of Neurology (SFN) adopted this journal as its official publication in the year of its foundation, 1899. The Revue Neurologique was published throughout the 20th century without interruption and is indexed in all international databases (including Current Contents, Pubmed, Scopus). Ten annual issues provide original peer-reviewed clinical and research articles, and review articles giving up-to-date insights in all areas of neurology. The Revue Neurologique also publishes guidelines and recommendations. The Revue Neurologique publishes original articles, brief reports, general reviews, editorials, and letters to the editor as well as correspondence concerning articles previously published in the journal in the correspondence column.
期刊最新文献
Editorial Board Contents CAR T-cell-associated neurotoxicity: A comprehensive review The immunology underlying CNS autoantibody diseases 40 years of autoantibody research in paraneoplastic neurological syndromes
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1