Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Alireza Ahmadzadeh, Mohammad Javad Ehsani Ardakani, Reza Mohamoud Robati
{"title":"细胞外基质是胰腺导管腺癌早期的主要靶环境。","authors":"Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Alireza Ahmadzadeh, Mohammad Javad Ehsani Ardakani, Reza Mohamoud Robati","doi":"10.22037/ghfbb.v16i4.2859","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.</p><p><strong>Background: </strong>PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.</p><p><strong>Methods: </strong>Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.</p><p><strong>Results: </strong>Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. \"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\" group of 52 biological terms were identified as the main affected terms.</p><p><strong>Conclusion: </strong>In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.</p>","PeriodicalId":12636,"journal":{"name":"Gastroenterology and Hepatology From Bed to Bench","volume":"16 4","pages":"401-407"},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10835096/pdf/","citationCount":"0","resultStr":"{\"title\":\"Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.\",\"authors\":\"Vahid Mansouri, Babak Arjmand, Maryam Hamzeloo-Moghadam, Zahra Razzaghi, Alireza Ahmadzadeh, Mohammad Javad Ehsani Ardakani, Reza Mohamoud Robati\",\"doi\":\"10.22037/ghfbb.v16i4.2859\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.</p><p><strong>Background: </strong>PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.</p><p><strong>Methods: </strong>Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.</p><p><strong>Results: </strong>Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. \\\"Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13\\\" group of 52 biological terms were identified as the main affected terms.</p><p><strong>Conclusion: </strong>In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.</p>\",\"PeriodicalId\":12636,\"journal\":{\"name\":\"Gastroenterology and Hepatology From Bed to Bench\",\"volume\":\"16 4\",\"pages\":\"401-407\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10835096/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gastroenterology and Hepatology From Bed to Bench\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22037/ghfbb.v16i4.2859\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology and Hepatology From Bed to Bench","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22037/ghfbb.v16i4.2859","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
Extracellular matrix is the main targeted environment in early stage of pancreatic ductal adenocarcinoma.
Aim: Due to weak diagnosis and treatment of pancreatic ductal adenocarcinoma (PDAC), detection of PDAC possible biomarkers in early stage is the main aim of this study.
Background: PDAC is known as an exocrine cancer with a 5-year overall survival of 11%.
Methods: Gene expression profiles of early stage of PDAC tissue and normal tissue are downloaded from gene expression omnibus (GEO) and evaluated via GEO2R. The significant differentially expressed genes (DEGs) are investigated via protein-protein interaction (PPI) network analysis and gene ontology.
Results: Among 104 DEGs, ALB, COL1A1, COL1A2, MMP1, POSTN, PLAU, and COL3A1 were pointed out as hub nodes. "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" group of 52 biological terms were identified as the main affected terms.
Conclusion: In conclusion, ALB, MMP1, and COL1A1 genes were highlighted as possible biomarkers of early stage of PDAC. Dysfunction of extracellular matrix was identified as a main event in patients.
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