在 SARS-CoV-2 的尖峰蛋白中寻找新的潜在 T 细胞和 B 细胞表位

IF 0.6 4区材料科学 Q4 CRYSTALLOGRAPHY Crystallography Reports Pub Date : 2024-02-05 DOI:10.1134/s1063774523601089

I. A. Kolesnikov, V. I. Timofeev, M. V. Nikolenko, A. V. Ermakov, A. S. Ivanovsky, Yu. A. Dyakova, Yu. V. Pisarevsky, M. V. Kovalchuk

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引用次数: 0

摘要

摘要当前的流行病学形势，包括具有高致突变性的新型 SARS-CoV-2 病毒的存在，要求从根本上重新确定疫苗的开发期限，而这只有应用现代计算技术和模拟才能实现。利用免疫信息学方法在 SARS-CoV-2 病毒的尖峰蛋白中发现了表位，并预测了它们的致敏性和免疫原性。结果表明，可以根据这些表位设计 SARS-CoV-2 疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Search for New Potential T-Cell and B-Cell Epitopes in the Spike Protein of SARS-CoV-2

Abstract

The current epidemiological situation, including the existence of new SARS-CoV-2 virus with a high mutagenicity, requires fundamentally new deadlines for the development of vaccines, which may be achieved only applying modern computing technologies and simulation. Epitopes have been found in the spike protein of the SARS-CoV-2 virus using immunoinformatics methods, and their allergenicity and immunogenecity was predicted. It is shown that a vaccine against SARS-CoV-2 can be designed based on these epitopes.

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来源期刊

Crystallography Reports 化学-晶体学

CiteScore

1.10

自引率

28.60%

发文量

审稿时长

4-8 weeks

期刊介绍： Crystallography Reports is a journal that publishes original articles short communications, and reviews on various aspects of crystallography: diffraction and scattering of X-rays, electrons, and neutrons, determination of crystal structure of inorganic and organic substances, including proteins and other biological substances; UV-VIS and IR spectroscopy; growth, imperfect structure and physical properties of crystals; thin films, liquid crystals, nanomaterials, partially disordered systems, and the methods of studies.