非肌层浸润性膀胱癌患者补充硒和维生素 E。

IF 12.1 1区医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Urology Pub Date : 2024-02-05 DOI:10.1038/s41585-024-00859-x

Shaun J. Trecarten, Robert S. Svatek

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引用次数: 0

摘要

在 SELENIB 试验中，硒和维生素 E 作为非肌层浸润性膀胱癌（NMIBC）的化学预防药物与安慰剂进行了比较。与安慰剂相比，硒在无复发间隔期（RFI）方面未观察到差异，但维生素 E 与更差的无复发间隔期有关。在对 NMIBC 进行化学预防时，不能推荐使用硒和维生素 E。此外，应让服用补充维生素 E 的 NMIBC 患者意识到，维生素 E 可能会导致 RFI 下降。

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Supplementary selenium and vitamin E in non-muscle-invasive bladder cancer

In the SELENIB trial, selenium and vitamin E were compared with placebo as chemoprevention for non-muscle-invasive bladder cancer (NMIBC). No difference versus placebo was observed in recurrence-free interval (RFI) with selenium, but vitamin E was associated with worse RFI. Selenium and vitamin E cannot be recommended in chemoprevention for NMIBC. Furthermore, patients with NMIBC taking supplemental vitamin E should be made aware of its potential association with worse RFI.

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来源期刊

Nature Reviews Urology 医学-泌尿学与肾脏学

CiteScore

12.50

自引率

2.60%

发文量

123

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Urology is part of the Nature Reviews portfolio of journals.Nature Reviews' basic, translational and clinical content is written by internationally renowned basic and clinical academics and researchers. This journal targeted readers in the biological and medical sciences, from the postgraduate level upwards, aiming to be accessible to professionals in any biological or medical discipline. The journal features authoritative In-depth Reviews providing up-to-date information on topics within a field's history and development. Perspectives, News & Views articles, and the Research Highlights section offer topical discussions and opinions, filtering primary research from various medical journals. Covering a wide range of subjects, including andrology, urologic oncology, and imaging, Nature Reviews provides valuable insights for practitioners, researchers, and academics within urology and related fields.