Atefeh Eivazi, Bahman Akbari, Sara Falahi, Ali Gorgin Karaji, Alireza Rezaiemanesh, Seyed Hamid Reza Mortazavi, Niloofar Daneshfar, Farhad Salari
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引用次数: 0
摘要
背景：过敏性鼻炎（AR）是一种鼻粘膜炎症性疾病，由接触环境过敏原引起。众所周知，15-脂氧合酶（15-LOX）参与了抗炎脂质介质的生物合成途径，包括溶血素和保护素：本研究以130名AR患者和130名健康对照者为对象，利用SNPinfo和Regulome DB工具研究AR易感性与花生四烯酸15-LOX（ALOX15）基因内含子区的两个选定单核苷酸多态性（SNPs），即rs2619112:A>G和rs7217186:C>T的相关性：结果表明，rs7217186：结果表明：与 CC 基因型相比，rs7217186：C>T 的 CT 基因型与 AR 风险的增加明显相关（P= 0.037，OR=1.943，CI：1.038-0.638）。然而，没有强有力的证据表明 rs2619112: A>G 与 AR 易感性有关（P> 0.05）：本研究结果表明，ALOX15 基因的 rs7217186 多态性可能是 AR 易感性的潜在生物标志物。
Association of Rs7217186 Polymorphism of Arachidonic Acid 15-Lipoxygenase (ALOX15) Gene with Susceptibility to Allergic Rhinitis.
Background: Allergic rhinitis (AR) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. It is known that 15-lipoxygenase (15-LOX) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins.
Methods: In this study, which was performed on 130 AR patients and 130 healthy controls, we aimed to investigate the association of susceptibility to AR with two selected single-nucleotide polymorphisms (SNPs), that is, rs2619112:A>G and rs7217186:C>T, in the intron regions of arachidonic acid 15-LOX (ALOX15) gene, using SNPinfo and Regulome DB tools.
Results: The results showed that the CT genotype of rs7217186: C>T was significantly associated with the increased risk of AR compared to the CC genotype (P= 0.037, OR=1.943, CI: 1.038-0.638). However, there was no strong evidence of the association of rs2619112: A>G with susceptibility to AR (P> 0.05).
Conclusions: The present results indicated that rs7217186 polymorphism of ALOX15 gene might be a potential biomarker for susceptibility to AR.
期刊介绍：
The Reports of Biochemistry & Molecular Biology (RBMB) is the official journal of the Varastegan Institute for Medical Sciences and is dedicated to furthering international exchange of medical and biomedical science experience and opinion and a platform for worldwide dissemination. The RBMB is a medical journal that gives special emphasis to biochemical research and molecular biology studies. The Journal invites original and review articles, short communications, reports on experiments and clinical cases, and case reports containing new insights into any aspect of biochemistry and molecular biology that are not published or being considered for publication elsewhere. Publications are accepted in the form of reports of original research, brief communications, case reports, structured reviews, editorials, commentaries, views and perspectives, letters to authors, book reviews, resources, news, and event agenda.
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