回顾心脏与冠状动脉的相互作用以及数学建模的启示。

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2024-05-01 Epub Date: 2024-02-05 DOI:10.1002/wsbm.1642
Lei Fan, Haifeng Wang, Ghassan S Kassab, Lik Chuan Lee
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引用次数: 0

摘要

心脏与冠状动脉的相互作用是心脏功能的基础。作为人体新陈代谢最旺盛的器官之一,心脏对氧气的需求是通过冠状动脉血管的血液灌注来满足的。冠状血管主要位于心肌组织内,心肌组织不断收缩,从而挤压血管。心肌与冠状动脉血管之间的相互作用是双向和复杂的。在此,我们将回顾不同类型的心肌-冠状动脉相互作用,并重点介绍从数学模型中获得的启示。具体来说,我们将考虑以下几点:(1)心肌-血管机械相互作用;(2)代谢-血流相互作用和调节;(3)灌注-收缩匹配;以及(4)心肌和冠状动脉血管之间的慢性相互作用。我们还讨论了不同类型心脏与冠状动脉相互作用的相关实验和临床研究。最后,我们强调了现有数学模型的知识差距、主要挑战和局限性,以及未来的研究方向,以了解心脏中独特的心肌-冠状动脉耦合。本文归类于心血管疾病 > 计算模型 心血管疾病 > 生物医学工程 心血管疾病 > 分子和细胞生理学。
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Review of cardiac-coronary interaction and insights from mathematical modeling.

Cardiac-coronary interaction is fundamental to the function of the heart. As one of the highest metabolic organs in the body, the cardiac oxygen demand is met by blood perfusion through the coronary vasculature. The coronary vasculature is largely embedded within the myocardial tissue which is continually contracting and hence squeezing the blood vessels. The myocardium-coronary vessel interaction is two-ways and complex. Here, we review the different types of cardiac-coronary interactions with a focus on insights gained from mathematical models. Specifically, we will consider the following: (1) myocardial-vessel mechanical interaction; (2) metabolic-flow interaction and regulation; (3) perfusion-contraction matching, and (4) chronic interactions between the myocardium and coronary vasculature. We also provide a discussion of the relevant experimental and clinical studies of different types of cardiac-coronary interactions. Finally, we highlight knowledge gaps, key challenges, and limitations of existing mathematical models along with future research directions to understand the unique myocardium-coronary coupling in the heart. This article is categorized under: Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Biomedical Engineering Cardiovascular Diseases > Molecular and Cellular Physiology.

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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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