Cara Esposito, Kenneth Tzan, Priscilla Machado, Flemming Forsberg, Jaydev K Dave
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This study aims to elucidate the effects of iodinated contrast (Visipaque, GE HealthCare) on subharmonic signal amplitude from contrast microbubbles (Definity, Lantheus Medical Imaging, Inc.). In an acrylic water tank, 0.06 mL of Definity and varied amounts of Visipaque (0.14, 0.43, 0.85, and 1.70 mL) were added to 425 mL of deionized water. Ultrasound scanning was performed with a SonixTablet scanner (BK Medical Systems) using optimized parameters for SHAPE with Definity (<i>f</i><sub>transmit/receive</sub> = 3.0/1.5 MHz; chirp down pulse). Subharmonic data was acquired and analyzed at 9 different incident acoustic outputs (<i>n</i> = 3). Results showed an increase in subharmonic signal amplitude from Definity microbubbles in the presence of 0.14 mL Visipaque by 2.8 ± 1.3 dB (<i>p</i> < .001), no change with 0.85 mL Visipaque (0.7 ± 1.2 dB; <i>p</i> = .09) and a decrease in subharmonic amplitude in the presence of 1.70 mL Visipaque by 1.9 ± 0.7 dB (<i>p</i> < .001). While statistically significant effect on subharmonic signal amplitude of Definity microbubbles was noted due to the mixture, the magnitude of the effect was minimal (~2.8 dB) and unlikely to impact <i>in vivo</i> SHAPE measurements.</p>","PeriodicalId":49401,"journal":{"name":"Ultrasonic Imaging","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Effect of Mixing Iodinated Contrast Media and Ultrasound Contrast Agents on Subharmonic Signals.\",\"authors\":\"Cara Esposito, Kenneth Tzan, Priscilla Machado, Flemming Forsberg, Jaydev K Dave\",\"doi\":\"10.1177/01617346241227971\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Subharmonic aided pressure estimation (SHAPE) is a technique that utilizes subharmonic signals from microbubble contrast agents for pressure estimation. 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引用次数: 0
摘要
次谐波辅助压力估算(SHAPE)是一种利用微气泡造影剂的次谐波信号进行压力估算的技术。SHAPE 技术的验证依赖于使用造影剂微气泡和压力导管(参考标准)对体内压力的同步测量。为了引导和放置体内压力导管,需要在透视下使用碘造影剂。因此,在 SHAPE 技术验证研究的数据采集过程中,造影剂微泡和碘化造影剂同时存在于血管中。本研究旨在阐明碘化造影剂(Visipaque,GE HealthCare)对造影剂微气泡(Definity,Lantheus Medical Imaging,Inc.)在丙烯酸水箱中,将 0.06 mL Definity 和不同量的 Visipaque(0.14、0.43、0.85 和 1.70 mL)加入 425 mL 去离子水中。超声扫描由 SonixTablet 扫描仪(BK 医疗系统公司)进行,使用 Definity 的 SHAPE 优化参数(发射/接收频率 = 3.0/1.5 MHz;啁啾向下脉冲)。在 9 个不同的入射声输出(n = 3)下采集并分析了次谐波数据。结果显示,在有 0.14 mL Visipaque 的情况下,Definity 微气泡的次谐波信号幅度增加了 2.8 ± 1.3 dB(p p = .09),而在有 1.70 mL Visipaque 的情况下,次谐波幅度降低了 1.9 ± 0.7 dB(p 在体内 SHAPE 测量中。
The Effect of Mixing Iodinated Contrast Media and Ultrasound Contrast Agents on Subharmonic Signals.
Subharmonic aided pressure estimation (SHAPE) is a technique that utilizes subharmonic signals from microbubble contrast agents for pressure estimation. Validation of the SHAPE technique relies on synchronous measurements of in vivo pressures using contrast microbubbles and a pressure catheter (reference standard). For the guidance and placement of pressure catheter in vivo, iodinated contrast is used with fluoroscopy. Therefore, during data acquisition for validation studies of the SHAPE technique, both contrast microbubbles and iodinated contrast are present simultaneously within the vasculature. This study aims to elucidate the effects of iodinated contrast (Visipaque, GE HealthCare) on subharmonic signal amplitude from contrast microbubbles (Definity, Lantheus Medical Imaging, Inc.). In an acrylic water tank, 0.06 mL of Definity and varied amounts of Visipaque (0.14, 0.43, 0.85, and 1.70 mL) were added to 425 mL of deionized water. Ultrasound scanning was performed with a SonixTablet scanner (BK Medical Systems) using optimized parameters for SHAPE with Definity (ftransmit/receive = 3.0/1.5 MHz; chirp down pulse). Subharmonic data was acquired and analyzed at 9 different incident acoustic outputs (n = 3). Results showed an increase in subharmonic signal amplitude from Definity microbubbles in the presence of 0.14 mL Visipaque by 2.8 ± 1.3 dB (p < .001), no change with 0.85 mL Visipaque (0.7 ± 1.2 dB; p = .09) and a decrease in subharmonic amplitude in the presence of 1.70 mL Visipaque by 1.9 ± 0.7 dB (p < .001). While statistically significant effect on subharmonic signal amplitude of Definity microbubbles was noted due to the mixture, the magnitude of the effect was minimal (~2.8 dB) and unlikely to impact in vivo SHAPE measurements.
期刊介绍:
Ultrasonic Imaging provides rapid publication for original and exceptional papers concerned with the development and application of ultrasonic-imaging technology. Ultrasonic Imaging publishes articles in the following areas: theoretical and experimental aspects of advanced methods and instrumentation for imaging