Francesca Barilli, Cecilia Basile, Giuseppe DE Bernardo, Francesca Morlino, Giulia Manganelli, Maurizio Giordano, Petrina Bastrenta, Gian V Zuccotti, Gianluca Lista
{"title":"健康足月和近足月新生儿脐带残端局部用药与干性护理的比较:一项双中心前瞻性队列研究。","authors":"Francesca Barilli, Cecilia Basile, Giuseppe DE Bernardo, Francesca Morlino, Giulia Manganelli, Maurizio Giordano, Petrina Bastrenta, Gian V Zuccotti, Gianluca Lista","doi":"10.23736/S2724-5276.23.07411-6","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Proper umbilical cord stump care during the first days of life (both in hospital and at home) should not be overlooked to prevent possible complications (e.g., purulent discharge, granulomas, or periumbilical erythema or omphalitis). Despite the known benefits of its correct execution, the care of umbilical cord stump remains controversial, and many different approaches are described. The World Health Organization suggests the use of dry cord stump care (easy and economic technique) in developed countries, but in many cases in the real life various topical antiseptics are used in combination with dry cord stump. The extracts of Arnica Montana (AM) have been reported to possess antibacterial, anti-inflammatory, antifungal, and immunomodulatory activities, very useful in the management of cord stump in full term infants.</p><p><strong>Methods: </strong>In our study we evaluated the efficacy of a powder containing AM (study group- GrA) versus dry cord stump (control group-GrB) in a population of healthy newborn >35 weeks of gestational age (GA).</p><p><strong>Results: </strong>Three hundred twenty-six neonates (mean GA 39±1 in both groups and body weight 3200 g and 3400±448 g respectively in GrA and GrB) were enrolled in two standard neonatal care units (163 neonates in GrA and 163 in GrB). At T1 (48 hours after discharge) GrA showed significantly reduced incidence of mild complications in toto, in particular a lower rate of wet umbilical cord stump). No differences between the two groups at T2 (1 week after discharge).</p><p><strong>Conclusions: </strong>The use of a natural topical dermo-protective powder containing AM reduces the risk of minor complications, both nurse and parental workload in the first days after discharge, but does not have an impact on cord detachment and other complications in neonates >35 weeks GA.</p>","PeriodicalId":56337,"journal":{"name":"Minerva Pediatrics","volume":null,"pages":null},"PeriodicalIF":1.0000,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Umbilical cord stump medication with a topical dermo protective powder compared to dry care in healthy full-term and near-term newborns: a two-center prospective cohort study.\",\"authors\":\"Francesca Barilli, Cecilia Basile, Giuseppe DE Bernardo, Francesca Morlino, Giulia Manganelli, Maurizio Giordano, Petrina Bastrenta, Gian V Zuccotti, Gianluca Lista\",\"doi\":\"10.23736/S2724-5276.23.07411-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Proper umbilical cord stump care during the first days of life (both in hospital and at home) should not be overlooked to prevent possible complications (e.g., purulent discharge, granulomas, or periumbilical erythema or omphalitis). Despite the known benefits of its correct execution, the care of umbilical cord stump remains controversial, and many different approaches are described. The World Health Organization suggests the use of dry cord stump care (easy and economic technique) in developed countries, but in many cases in the real life various topical antiseptics are used in combination with dry cord stump. The extracts of Arnica Montana (AM) have been reported to possess antibacterial, anti-inflammatory, antifungal, and immunomodulatory activities, very useful in the management of cord stump in full term infants.</p><p><strong>Methods: </strong>In our study we evaluated the efficacy of a powder containing AM (study group- GrA) versus dry cord stump (control group-GrB) in a population of healthy newborn >35 weeks of gestational age (GA).</p><p><strong>Results: </strong>Three hundred twenty-six neonates (mean GA 39±1 in both groups and body weight 3200 g and 3400±448 g respectively in GrA and GrB) were enrolled in two standard neonatal care units (163 neonates in GrA and 163 in GrB). At T1 (48 hours after discharge) GrA showed significantly reduced incidence of mild complications in toto, in particular a lower rate of wet umbilical cord stump). No differences between the two groups at T2 (1 week after discharge).</p><p><strong>Conclusions: </strong>The use of a natural topical dermo-protective powder containing AM reduces the risk of minor complications, both nurse and parental workload in the first days after discharge, but does not have an impact on cord detachment and other complications in neonates >35 weeks GA.</p>\",\"PeriodicalId\":56337,\"journal\":{\"name\":\"Minerva Pediatrics\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2024-02-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Minerva Pediatrics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.23736/S2724-5276.23.07411-6\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Minerva Pediatrics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.23736/S2724-5276.23.07411-6","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0
摘要
背景:生命最初几天(无论是在医院还是在家中)的脐带残端正确护理不容忽视,以防止可能出现的并发症(如脓性分泌物、肉芽肿、脐周红斑或脐炎)。尽管众所周知正确处理脐带残端有很多好处,但护理脐带残端仍存在争议,有很多不同的方法。世界卫生组织建议发达国家使用干性脐带残端护理(简单经济的技术),但在现实生活中,很多情况下各种外用杀菌剂与干性脐带残端结合使用。据报道,山金车(AM)提取物具有抗菌、消炎、抗真菌和免疫调节活性,对足月儿脐带残端护理非常有用:在这项研究中,我们在胎龄大于 35 周的健康新生儿中评估了含有 AM 的粉末(研究组-GrA)与干燥脐带残端(对照组-GrB)的疗效:两个标准新生儿护理病房共接收了 326 名新生儿(两组的平均胎龄均为 39±1,体重分别为 3200 g 和 3400±448 g)(GrA 组和 GrB 组各 163 名新生儿)。在 T1(出院后 48 小时),GrA 组轻度并发症的发生率明显降低,尤其是脐带残端湿润的发生率较低)。两组在 T2(出院后 1 周)时无差异:结论:使用含有AM成分的天然外用皮肤保护粉可降低轻微并发症的风险,减轻出院后最初几天护士和家长的工作量,但对胎龄大于35周的新生儿的脐带脱落和其他并发症没有影响。
Umbilical cord stump medication with a topical dermo protective powder compared to dry care in healthy full-term and near-term newborns: a two-center prospective cohort study.
Background: Proper umbilical cord stump care during the first days of life (both in hospital and at home) should not be overlooked to prevent possible complications (e.g., purulent discharge, granulomas, or periumbilical erythema or omphalitis). Despite the known benefits of its correct execution, the care of umbilical cord stump remains controversial, and many different approaches are described. The World Health Organization suggests the use of dry cord stump care (easy and economic technique) in developed countries, but in many cases in the real life various topical antiseptics are used in combination with dry cord stump. The extracts of Arnica Montana (AM) have been reported to possess antibacterial, anti-inflammatory, antifungal, and immunomodulatory activities, very useful in the management of cord stump in full term infants.
Methods: In our study we evaluated the efficacy of a powder containing AM (study group- GrA) versus dry cord stump (control group-GrB) in a population of healthy newborn >35 weeks of gestational age (GA).
Results: Three hundred twenty-six neonates (mean GA 39±1 in both groups and body weight 3200 g and 3400±448 g respectively in GrA and GrB) were enrolled in two standard neonatal care units (163 neonates in GrA and 163 in GrB). At T1 (48 hours after discharge) GrA showed significantly reduced incidence of mild complications in toto, in particular a lower rate of wet umbilical cord stump). No differences between the two groups at T2 (1 week after discharge).
Conclusions: The use of a natural topical dermo-protective powder containing AM reduces the risk of minor complications, both nurse and parental workload in the first days after discharge, but does not have an impact on cord detachment and other complications in neonates >35 weeks GA.