切除胃神经内分泌肿瘤患者三级淋巴结构的浸润特征和预后价值

IF 4.6 2区 医学 Q2 IMMUNOLOGY Clinical & Translational Immunology Pub Date : 2024-02-05 DOI:10.1002/cti2.1489
Daming Cai, Xingzhou Wang, Heng Yu, Chunhua Bai, Yonghuan Mao, Mengjie Liang, Xuefeng Xia, Song Liu, Meng Wang, Xiaofeng Lu, Junfeng Du, Xiaofei Shen, Wenxian Guan
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引用次数: 0

摘要

目的 三级淋巴结构(TLS)是淋巴细胞聚集体,在大多数实体瘤中发挥抗肿瘤作用。然而,三级淋巴结构在胃神经内分泌肿瘤(GNENs)中的功能尚不清楚。本研究旨在确定切除的胃神经内分泌瘤患者体内 TLS 的特征和预后价值。 方法 采用血色素-伊红、免疫组织化学(IHC)和多重荧光 IHC 染色法评估 TLS,研究 TLS 与临床病理特征的相关性及其预后价值。 结果 84.3%的 GNEN 患者发现了三级淋巴结构。它们位于基质区或肿瘤组织外,主要由 B 细胞和 T 细胞组成。高密度的三级淋巴结构促进了 GNEN 的抗肿瘤免疫反应。TLSs中的CD15+ TANs和FOXP3+ Tregs抑制了TLSs的形成。高TLS密度与GNENs无复发生存期(RFS)和总生存期(OS)的延长明显相关。单变量和多变量考克斯回归分析显示,TLS密度、肿瘤大小、肿瘤-结节-转移(TNM)分期和世界卫生组织(WHO)分类是OS的独立预后因素,而TLS密度、肿瘤大小和TNM分期是RFS的独立预后因素。最后,制定并验证了OS和RFS提名图,该提名图优于WHO分类和TNM分期。 结论 三级淋巴结构主要位于基质区或肿瘤区以外,TLS密度高与GNEN患者的良好预后显著相关。将 TLS 密度纳入提名图可能会改善对切除 GNEN 患者的生存预测。
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Infiltrating characteristics and prognostic value of tertiary lymphoid structures in resected gastric neuroendocrine neoplasm patients

Objectives

Tertiary lymphoid structures (TLSs) are lymphocyte aggregates that play an anti-tumor role in most solid tumors. However, the functions of TLS in gastric neuroendocrine neoplasms (GNENs) remain unknown. This study aimed to determine the characteristics and prognostic values of TLS in resected GNEN patients.

Methods

Haematoxylin–eosin, immunohistochemistry (IHC) and multiple fluorescent IHC staining were used to assess TLS to investigate the correlation between TLSs and clinicopathological characteristics and its prognostic value.

Results

Tertiary lymphoid structures were identified in 84.3% of patients with GNEN. They were located in the stromal area or outside the tumor tissue and mainly composed of B and T cells. A high density of TLSs promoted an anti-tumor immune response in GNEN. CD15+ TANs and FOXP3+ Tregs in TLSs inhibited the formation of TLSs. High TLS density was significantly associated with prolonged recurrence-free survival (RFS) and overall survival (OS) of GNENs. Univariate and multivariate Cox regression analyses revealed that TLS density, tumor size, tumor–node–metastasis (TNM) stage and World Health Organisation (WHO) classification were independent prognostic factors for OS, whereas TLS density, tumor size and TNM stage were independent prognostic factors for RFS. Finally, OS and RFS nomograms were developed and validated, which were superior to the WHO classification and the TNM stage.

Conclusion

Tertiary lymphoid structures were mainly located in the stromal area or outside the tumor area, and high TLS density was significantly associated with the good prognosis of patients with GNEN. Incorporating TLS density into a nomogram may improve survival prediction in patients with resected GNEN.

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来源期刊
Clinical & Translational Immunology
Clinical & Translational Immunology Medicine-Immunology and Allergy
CiteScore
12.00
自引率
1.70%
发文量
77
审稿时长
13 weeks
期刊介绍: Clinical & Translational Immunology is an open access, fully peer-reviewed journal devoted to publishing cutting-edge advances in biomedical research for scientists and physicians. The Journal covers fields including cancer biology, cardiovascular research, gene therapy, immunology, vaccine development and disease pathogenesis and therapy at the earliest phases of investigation.
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