重症外科疾病中非编码 RNA 对肠道黏膜生长和适应的转录后调控。

IF 2.1 4区 医学 Q2 SURGERY Journal of Investigative Surgery Pub Date : 2024-12-01 Epub Date: 2024-02-07 DOI:10.1080/08941939.2024.2308809
Cassandra A Cairns, Lan Xiao, Jian-Ying Wang
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引用次数: 0

摘要

人体肠道上皮对损伤的反应能力令人印象深刻,在各种病理生理条件下,肠道上皮都能通过良好的调节机制维持体内平衡。然而,在重症手术患者中,肠上皮的急性损伤和再生受抑制的情况时有发生,导致肠腔内有毒物质和细菌转移到血液中。保护肠上皮完整性、预防粘膜出血和肠道屏障功能障碍的有效疗法十分有限,这主要是因为人们对粘膜破坏的基本机制了解甚少。非编码 RNA(ncRNA)包括微 RNA(miRNA)、长 ncRNA(lncRNA)、环状 RNA(circRNA)和小拱顶 RNA(vtRNA),可调节多种生物功能,已被确定为肠上皮稳态的协调者。在这里,我们将介绍许多重要的 ncRNA 在控制肠粘膜生长、屏障功能和损伤后修复方面的作用--尤其是在肠道手术后恢复的背景下。我们回顾了围绕 lncRNA、microRNA 和 RNA 结合蛋白之间关系的最新文献,以及它们之间的相互作用如何影响肠上皮细胞的存活、增殖、迁移和细胞间相互作用。随着对 ncRNA 生物学知识的不断深入,以及人们越来越认识到 ncRNA 在维持肠上皮完整性方面的重要性,ncRNA 为治疗提供了新的治疗靶点,以保护患有严重外科疾病的人的肠道上皮。
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Posttranscriptional Regulation of Intestinal Mucosal Growth and Adaptation by Noncoding RNAs in Critical Surgical Disorders.

The human intestinal epithelium has an impressive ability to respond to insults and its homeostasis is maintained by well-regulated mechanisms under various pathophysiological conditions. Nonetheless, acute injury and inhibited regeneration of the intestinal epithelium occur commonly in critically ill surgical patients, leading to the translocation of luminal toxic substances and bacteria to the bloodstream. Effective therapies for the preservation of intestinal epithelial integrity and for the prevention of mucosal hemorrhage and gut barrier dysfunction are limited, primarily because of a poor understanding of the mechanisms underlying mucosal disruption. Noncoding RNAs (ncRNAs), which include microRNAs (miRNAs), long ncRNAs (lncRNAs), circular RNAs (circRNAs), and small vault RNAs (vtRNAs), modulate a wide array of biological functions and have been identified as orchestrators of intestinal epithelial homeostasis. Here, we feature the roles of many important ncRNAs in controlling intestinal mucosal growth, barrier function, and repair after injury-particularly in the context of postoperative recovery from bowel surgery. We review recent literature surrounding the relationships between lncRNAs, microRNAs, and RNA-binding proteins and how their interactions impact cell survival, proliferation, migration, and cell-to-cell interactions in the intestinal epithelium. With advancing knowledge of ncRNA biology and growing recognition of the importance of ncRNAs in maintaining the intestinal epithelial integrity, ncRNAs provide novel therapeutic targets for treatments to preserve the gut epithelium in individuals suffering from critical surgical disorders.

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来源期刊
CiteScore
4.20
自引率
0.00%
发文量
114
审稿时长
6-12 weeks
期刊介绍: Journal of Investigative Surgery publishes peer-reviewed scientific articles for the advancement of surgery, to the ultimate benefit of patient care and rehabilitation. It is the only journal that encompasses the individual and collaborative efforts of scientists in human and veterinary medicine, dentistry, basic and applied sciences, engineering, and law and ethics. The journal is dedicated to the publication of outstanding articles of interest to the surgical research community.
期刊最新文献
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