肾脏健康和疾病中的 Sirtuins。

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-02-06 DOI:10.1038/s41581-024-00806-4
Luca Perico, Giuseppe Remuzzi, Ariela Benigni
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摘要

Sirtuins(SIRTs)是模式生物寿命的推定调节因子。自最初发现 SIRTs 能促进线虫和苍蝇的寿命以来,对这些蛋白质其他特性的鉴定已使人们了解到它们作为精致的传感器将代谢活动与氧化状态联系起来的作用。SIRT 在对肾脏发育和生理功能非常重要的生物过程中发挥着重要作用,包括线粒体代谢、氧化应激、自噬、DNA 修复和炎症。此外,SIRT 活性的改变还与急性和慢性肾脏疾病的病理生理学和进展有关,包括急性肾损伤、糖尿病肾病、慢性肾病、多囊肾、自身免疫性疾病和肾衰老。SIRT 在这些疾病中的肾保护作用使其成为具有吸引力的治疗靶点。一些 SIRT 激活化合物已在肾脏疾病模型中显示出有益作用;然而,还需要进一步研究,以确定新型 SIRT 靶向策略,从而有可能治疗和/或预防肾脏疾病的进展,并延长人类的平均健康寿命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Sirtuins in kidney health and disease
Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation. Furthermore, altered SIRT activity has been implicated in the pathophysiology and progression of acute and chronic kidney diseases, including acute kidney injury, diabetic kidney disease, chronic kidney disease, polycystic kidney disease, autoimmune diseases and renal ageing. The renoprotective roles of SIRTs in these diseases make them attractive therapeutic targets. A number of SIRT-activating compounds have shown beneficial effects in kidney disease models; however, further research is needed to identify novel SIRT-targeting strategies with the potential to treat and/or prevent the progression of kidney diseases and increase the average human healthspan. This Review summarizes the roles of sirtuins in kidney development, physiological processes and the pathogenesis of acute and chronic kidney diseases. The authors also highlight the potential of sirtuins as therapeutic targets to limit human kidney disease and renal ageing.
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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