Elisabeth Lendoye, Ulysse Pascal Minkobame, Opheelia Makoyo Komba, Pamphile Assoumou Obiang, Luce Nkene Eya'a, Ulrich Bisvigou, Lydie Moukambi, Bénédicte Ndeboko, Jacques Albert Bang Ntamack, Edgard Brice Ngoungou, Joël Fleury Djoba Siawaya, Félix Ovono Abessolo, Jean François Meyé
{"title":"平均血压和胎盘生长因子在加蓬妇女子痫前期早期检测中的附加值。","authors":"Elisabeth Lendoye, Ulysse Pascal Minkobame, Opheelia Makoyo Komba, Pamphile Assoumou Obiang, Luce Nkene Eya'a, Ulrich Bisvigou, Lydie Moukambi, Bénédicte Ndeboko, Jacques Albert Bang Ntamack, Edgard Brice Ngoungou, Joël Fleury Djoba Siawaya, Félix Ovono Abessolo, Jean François Meyé","doi":"10.4103/npmj.npmj_232_23","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the use of the Foetal Medicine Foundation (FMF) algorithm in routine practice for early pre-eclampsia (PE) screening in Libreville.</p><p><strong>Materials and methods: </strong>We conducted a cohort study on pregnant women within their 11-13 + 6 weeks of gestation (WG). We had measured mean blood pressure (MBP), placental growth factor (PlGF), soluble Fms-like tyrosine kinase 1, Uterine Artery Pulsatility Index (UtA-PI) and resistance index (UtA-RI). Statistical analyses were considered significant for P < 0.05.</p><p><strong>Results: </strong>There were 30 participants. At the first quarter (T1), 36.7% of them were at high risk of PE according to the FMF algorithm and were consequently prescribed aspirin (100 mg/d). By the end of the observation period, we have found a 13% incidence of PE. MBP was higher in the higher risk PE group than in the lower risk group as early as the T1 (90 ± 6 vs. 81 ± 6 mmHg; P = 0.0007, threshold is >86 mmHg/area under the curve (AUC) = 0.86; P = 0.0012). It was the same for PlGF (58 ± 24 vs. 88 ± 38 pg/ml; P = 0.03; threshold is <71.98 pg/ml/AUC = 0.73; P = 0.03). At the second quarter (20-27 WG), biochemical markers did not change between the two groups. UtA-RI, UtA-PI and notch were unconclusive individually, but they are still very important for FMF algorithm application.</p><p><strong>Conclusion: </strong>Early detection of PE using the FMF algorithm is possible in routine practice in Gabon. MBP and PlGF levels at T1 seem to be very significant. However, the present study must continue to obtain the larger cohorts that would achieve more conclusive statistical analyses.</p>","PeriodicalId":19720,"journal":{"name":"Nigerian Postgraduate Medical Journal","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Added Value of Mean Blood Pressure and Placental Growth Factor in the Early Detection of Pre-eclampsia among Gabonese Women.\",\"authors\":\"Elisabeth Lendoye, Ulysse Pascal Minkobame, Opheelia Makoyo Komba, Pamphile Assoumou Obiang, Luce Nkene Eya'a, Ulrich Bisvigou, Lydie Moukambi, Bénédicte Ndeboko, Jacques Albert Bang Ntamack, Edgard Brice Ngoungou, Joël Fleury Djoba Siawaya, Félix Ovono Abessolo, Jean François Meyé\",\"doi\":\"10.4103/npmj.npmj_232_23\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the use of the Foetal Medicine Foundation (FMF) algorithm in routine practice for early pre-eclampsia (PE) screening in Libreville.</p><p><strong>Materials and methods: </strong>We conducted a cohort study on pregnant women within their 11-13 + 6 weeks of gestation (WG). We had measured mean blood pressure (MBP), placental growth factor (PlGF), soluble Fms-like tyrosine kinase 1, Uterine Artery Pulsatility Index (UtA-PI) and resistance index (UtA-RI). Statistical analyses were considered significant for P < 0.05.</p><p><strong>Results: </strong>There were 30 participants. At the first quarter (T1), 36.7% of them were at high risk of PE according to the FMF algorithm and were consequently prescribed aspirin (100 mg/d). By the end of the observation period, we have found a 13% incidence of PE. MBP was higher in the higher risk PE group than in the lower risk group as early as the T1 (90 ± 6 vs. 81 ± 6 mmHg; P = 0.0007, threshold is >86 mmHg/area under the curve (AUC) = 0.86; P = 0.0012). It was the same for PlGF (58 ± 24 vs. 88 ± 38 pg/ml; P = 0.03; threshold is <71.98 pg/ml/AUC = 0.73; P = 0.03). At the second quarter (20-27 WG), biochemical markers did not change between the two groups. UtA-RI, UtA-PI and notch were unconclusive individually, but they are still very important for FMF algorithm application.</p><p><strong>Conclusion: </strong>Early detection of PE using the FMF algorithm is possible in routine practice in Gabon. MBP and PlGF levels at T1 seem to be very significant. However, the present study must continue to obtain the larger cohorts that would achieve more conclusive statistical analyses.</p>\",\"PeriodicalId\":19720,\"journal\":{\"name\":\"Nigerian Postgraduate Medical Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nigerian Postgraduate Medical Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/npmj.npmj_232_23\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/2/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nigerian Postgraduate Medical Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/npmj.npmj_232_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
摘要
目的评估胎儿医学基金会(FMF)算法在利伯维尔早期子痫前期(PE)筛查常规实践中的应用情况:我们对妊娠 11-13+6 周(WG)的孕妇进行了一项队列研究。我们测量了平均血压(MBP)、胎盘生长因子(PlGF)、可溶性 Fms 样酪氨酸激酶 1、子宫动脉脉动指数(UtA-PI)和阻力指数(UtA-RI)。统计分析以 P < 0.05 为有意义:共有 30 名参与者。在第一季度(T1),根据 FMF 算法,其中 36.7% 的人属于 PE 高危人群,因此被处方阿司匹林(100 毫克/天)。观察期结束时,我们发现 PE 的发病率为 13%。高风险 PE 组的 MBP 早在 T1 阶段就高于低风险组(90 ± 6 vs. 81 ± 6 mmHg;P = 0.0007,阈值为 >86 mmHg/曲线下面积 (AUC) = 0.86;P = 0.0012)。PlGF也是如此(58 ± 24 vs. 88 ± 38 pg/ml;P = 0.03;阈值为≥86 mmHg):在加蓬,使用 FMF 算法早期检测 PE 是可行的。T1 阶段的 MBP 和 PlGF 水平似乎非常重要。然而,本研究必须继续进行,以获得更大规模的队列,从而进行更具结论性的统计分析。
Added Value of Mean Blood Pressure and Placental Growth Factor in the Early Detection of Pre-eclampsia among Gabonese Women.
Objective: To evaluate the use of the Foetal Medicine Foundation (FMF) algorithm in routine practice for early pre-eclampsia (PE) screening in Libreville.
Materials and methods: We conducted a cohort study on pregnant women within their 11-13 + 6 weeks of gestation (WG). We had measured mean blood pressure (MBP), placental growth factor (PlGF), soluble Fms-like tyrosine kinase 1, Uterine Artery Pulsatility Index (UtA-PI) and resistance index (UtA-RI). Statistical analyses were considered significant for P < 0.05.
Results: There were 30 participants. At the first quarter (T1), 36.7% of them were at high risk of PE according to the FMF algorithm and were consequently prescribed aspirin (100 mg/d). By the end of the observation period, we have found a 13% incidence of PE. MBP was higher in the higher risk PE group than in the lower risk group as early as the T1 (90 ± 6 vs. 81 ± 6 mmHg; P = 0.0007, threshold is >86 mmHg/area under the curve (AUC) = 0.86; P = 0.0012). It was the same for PlGF (58 ± 24 vs. 88 ± 38 pg/ml; P = 0.03; threshold is <71.98 pg/ml/AUC = 0.73; P = 0.03). At the second quarter (20-27 WG), biochemical markers did not change between the two groups. UtA-RI, UtA-PI and notch were unconclusive individually, but they are still very important for FMF algorithm application.
Conclusion: Early detection of PE using the FMF algorithm is possible in routine practice in Gabon. MBP and PlGF levels at T1 seem to be very significant. However, the present study must continue to obtain the larger cohorts that would achieve more conclusive statistical analyses.