亨廷顿病中线粒体 DNA 的不稳定性

IF 28.2 1区 医学 Q1 CLINICAL NEUROLOGY Nature Reviews Neurology Pub Date : 2024-02-07 DOI:10.1038/s41582-024-00937-z
Lisa Kiani
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引用次数: 0

摘要

一项使用超深度线粒体DNA(mtDNA)测序的研究揭示了亨廷顿病中影响氧化磷酸化的突变累积。研究结果表明,高水平的突变亨廷汀蛋白片段会导致线粒体裂变增加和有丝分裂异常,从而导致mtDNA不稳定。研究人员认为,增强线粒体健康可为亨廷顿病提供一种辅助疗法。
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Mitochondrial DNA instability in Huntington disease
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来源期刊
Nature Reviews Neurology
Nature Reviews Neurology 医学-临床神经学
CiteScore
29.90
自引率
0.80%
发文量
138
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.
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