评估短时心脏磁共振成像用于乳腺癌心脏毒性评估的可行性和扫描间变异性

IF 3.8 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Radiology. Cardiothoracic imaging Pub Date : 2024-02-01 DOI:10.1148/ryct.220229
Yoo Jin Hong, Kyunghwa Han, Hye-Jeong Lee, Jin Hur, Young Jin Kim, Min Jung Kim, Byoung Wook Choi
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Interscan, intercoil, and interobserver reproducibility and variability of native T1 and extracellular volume (ECV), as well as ventricular functional parameters, were measured using the intraclass correlation coefficient (ICC), standard error of measurement (SEM), or coefficient of variation (CoV). Results Left ventricular functional parameters had excellent interscan reproducibility (ICC ≥ 0.80). Left ventricular ejection fraction showed low interscan variability in control and chemotherapy participants (SEM, 2.0 and 1.2; CoV, 3.1 and 1.9, respectively). Native T1 showed excellent interscan (ICC, 0.75) and intercoil (ICC, 0.81) reproducibility in the control group and good interscan reproducibility (ICC, 0.72 and 0.73, respectively) in the participants undergoing immediate and remote chemotherapy. 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引用次数: 0

摘要

目的 研究乳腺癌患者化疗后短时心脏 MRI 方案的可行性和扫描间变异性。材料和方法 对 13 名健康女性对照组(平均年龄为 52.4 岁 ± 13.2 [SD])和 85 名正在接受化疗的女性乳腺癌患者(平均年龄为 51.8 岁 ± 9.9)进行了前瞻性的常规乳腺 MRI 和短时心脏 MRI 扫描。使用类内相关系数 (ICC)、测量标准误差 (SEM) 或变异系数 (CoV) 测量原生 T1 和细胞外容积 (ECV) 以及心室功能参数的扫描间、线圈间和观察者间的重现性和变异性。结果 左心室功能参数的扫描间重现性极佳(ICC ≥ 0.80)。对照组和化疗组患者的左室射血分数扫描间变异性较低(SEM分别为2.0和1.2;CoV分别为3.1和1.9)。在对照组中,原位 T1 的扫描间重现性(ICC,0.75)和线圈间重现性(ICC,0.81)极佳,而在接受直接化疗和远程化疗的参与者中,扫描间重现性良好(ICC 分别为 0.72 和 0.73)。在对照组和远程化疗组中,ECV的扫描间再现性非常好(ICC分别为0.93和0.88),而在即时化疗组中,ECV的扫描间再现性一般(ICC为0.52)。在区域分析中,即刻化疗组的前隔或后隔原始T1和ECV的扫描间重复性和变异性优于其他节段。各组原始 T1 和 ECV 的观察者间一致性良好至极佳。结论 短时心脏磁共振成像在扫描间、线圈间、观察者间的再现性和心室功能或组织特征参数的变异性方面均显示出极佳的结果,表明这种方式可用于乳腺癌患者心脏毒性评估的常规监测。关键词心脏核磁共振 心脏 心肌病 ClinicalTrials.gov registration no.本文有补充材料。© RSNA, 2024.
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Assessment of Feasibility and Interscan Variability of Short-time Cardiac MRI for Cardiotoxicity Evaluation in Breast Cancer.

Purpose To investigate the feasibility and interscan variability of short-time cardiac MRI protocol after chemotherapy in individuals with breast cancer. Materials and Methods A total of 13 healthy female controls (mean age, 52.4 years ± 13.2 [SD]) and 85 female participants with breast cancer (mean age, 51.8 years ± 9.9) undergoing chemotherapy prospectively underwent routine breast MRI and short-time cardiac MRI using a 3-T scanner with peripheral pulse gating in the prone position. Interscan, intercoil, and interobserver reproducibility and variability of native T1 and extracellular volume (ECV), as well as ventricular functional parameters, were measured using the intraclass correlation coefficient (ICC), standard error of measurement (SEM), or coefficient of variation (CoV). Results Left ventricular functional parameters had excellent interscan reproducibility (ICC ≥ 0.80). Left ventricular ejection fraction showed low interscan variability in control and chemotherapy participants (SEM, 2.0 and 1.2; CoV, 3.1 and 1.9, respectively). Native T1 showed excellent interscan (ICC, 0.75) and intercoil (ICC, 0.81) reproducibility in the control group and good interscan reproducibility (ICC, 0.72 and 0.73, respectively) in the participants undergoing immediate and remote chemotherapy. Interscan reproducibility for ECV was excellent in the control group and in the remote chemotherapy group (ICC, 0.93 and 0.88, respectively) and fair in the immediate chemotherapy group (ICC, 0.52). In the regional analysis, interscan repeatability and variability of native T1 and ECV were superior in the anteroseptum or inferoseptum than in other segments in the immediate chemotherapy group. Native T1 and ECV had good to excellent interobserver agreement across all groups. Conclusion Short-time cardiac MRI showed excellent results for interscan, intercoil, and interobserver reproducibility and variability for ventricular functional or tissue characterization parameters, suggesting that this modality is feasible for routine surveillance of cardiotoxicity evaluation in individuals with breast cancer. Keywords: Cardiac MRI, Heart, Cardiomyopathy ClinicalTrials.gov registration no. NCT03301389 Supplemental material is available for this article. © RSNA, 2024.

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