Shir Forer, Guy J Ben Simon, Gahl Greenberg, Lital Smadar, Amit Zabatani, Mattan Arazi, Ido Didi Fabian, Vicktoria Vishnevskia-Dai, Daphna Landau-Prat
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Orbital Development in Children with Retinoblastoma: An Imaging-Based Study.
Purpose: To examine whether children treated for Retinoblastoma (Rb) have impaired orbital development.
Methods: A retrospective case series was performed among children with Rb treated at a single medical center from 2004 to 2020. Orbital volumes and measurements were assessed by 3-dimensional image processing software. The main outcome measures were differences in orbital growth between Rb and non-Rb eyes assessed at last follow-up.
Results: Among 44 patients included (mean age 16.09 ± 18.01 months), a positive correlation between age and orbital volume was observed only in the uninvolved, healthy eyes (p = .03). In unilateral cases, orbital growth in the horizontal, vertical, and depth planes was smaller on the affected side compared to the healthy eyes (p < .05). Orbits that underwent enucleation showed decreased growth over time compared to those treated conservatively (p = .017).
Conclusions: Orbital growth rate is slower in the orbits of children treated for Rb compared to healthy orbits. Enucleation negatively affects orbital growth.
期刊介绍：
Seminars in Ophthalmology offers current, clinically oriented reviews on the diagnosis and treatment of ophthalmic disorders. Each issue focuses on a single topic, with a primary emphasis on appropriate surgical techniques.
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