SUMO 蛋白酶:从细胞功能到疾病。

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-11-01 Epub Date: 2024-02-06 DOI:10.1016/j.tcb.2024.01.002
Laura A Claessens, Alfred C O Vertegaal
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引用次数: 0

摘要

小型泛素样修饰物(SUMOs)的翻译后修饰在调节基因表达、细胞周期进展、基因组完整性、细胞新陈代谢以及炎症和免疫等多种细胞过程中至关重要。通过 SUMO 连接酶和解连接酶的协同作用,SUMOs 与目标蛋白质的共价连接是高度动态和可逆的。在哺乳动物细胞中,中性蛋白特异性蛋白酶(SENPs)是最丰富的解结合酶家族。本综述重点介绍了我们对 SENPs 底物、细胞和生理过程控制的最新认识进展。值得注意的是,SENPs 正在成为癌症和其他疾病中的重要角色,使它们成为有吸引力的治疗干预目标。因此,该领域正致力于开发 SENP 抑制剂。
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SUMO proteases: from cellular functions to disease.

Posttranslational modification by small ubiquitin-like modifiers (SUMOs) is critical in regulating diverse cellular processes including gene expression, cell cycle progression, genome integrity, cellular metabolism, and inflammation and immunity. The covalent attachment of SUMOs to target proteins is highly dynamic and reversible through the concerted action of SUMO conjugating and deconjugating enzymes. In mammalian cells, sentrin-specific proteases (SENPs) are the most abundant family of deconjugating enzymes. This review highlights recent advances in our knowledge of the substrates and cellular and physiological processes controlled by SENPs. Notably, SENPs are emerging as significant players in cancer, as well as in other diseases, making them attractive targets for therapeutic intervention. Consequently, a growing amount of effort in the field is being directed towards the development of SENP inhibitors.

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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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