肾移植后胃伯基特单形性移植后淋巴组织增生症：病例报告。

IF 1.1 4区医学 Q3 UROLOGY & NEPHROLOGY Clinical nephrology Pub Date : 2024-05-01 DOI:10.5414/CN111321

Yusuke Yoshimura, Tatsuya Suwabe, Arisa Fujiki, Daisuke Kaji, Yuki Asano-Mori, Yuki Oba, Hiroki Mizuno, Masayuki Yamanouchi, Kiho Tanaka, Eiko Hasegawa, Katsuyuki Miki, Takayoshi Yokoyama, Yuki Namamura, Yasuo Ishii, Satoshi Yamashita, Kei Kono, Keiichi Kinowaki, Yutaka Takazawa, Naoki Sawa, Yoshifumi Ubara

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引用次数: 0

摘要

我们报告了一名53岁的日本男子在埃塞俄比亚接受肾移植28个月后，因胃部不适接受内镜检查，被诊断为胃伯基特单形性移植后淋巴组织增生性疾病（B-PTLD）。移植前血清爱泼斯坦-巴氏病毒（EBV）检测呈阴性，但在B-PTLD发病时，胃活检收集的肿瘤细胞显示EBV编码的小核糖核酸（EBER）呈阳性。从R（利妥昔单抗）-CHOP疗法开始的强化治疗，再加上DA-EPOCH-R疗法，疗效显著，至今尚未复发。Burkitt 淋巴瘤预后较差，但 B-PTLD 可以通过大剂量化疗得到有效治疗。这是一例罕见的日本患者胃B-PTLD病例。

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Gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder after kidney transplantation: A case report.

We report on a 53-year-old Japanese man diagnosed with gastric Burkitt's monomorphic post-transplant lymphoproliferative disorder (B-PTLD) after endoscopy for gastric discomfort 28 months after the patient underwent renal transplantation in Ethiopia. Serum Epstein-Barr virus (EBV) tests were negative before transplantation, but the tumor cells collected from a gastric biopsy showed positive EBV-encoded small RNAs (EBER) at B-PTLD onset. Intensive treatment started with R(rituximab)-CHOP therapy and continued with DA-EPOCH-R therapy has been effective, and relapse has not yet occurred. Burkitt lymphoma has a poor prognosis, but B-PTLD may be effectively treated with high-dose chemotherapy. This is a rare case of gastric B-PTLD in a Japanese patient.

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来源期刊

Clinical nephrology 医学-泌尿学与肾脏学

CiteScore

2.10

自引率

9.10%

发文量

138

审稿时长

4-8 weeks

期刊介绍： Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.