感染相关缺血性中风的新方向。

IF 2.9 3区 医学 Q2 CLINICAL NEUROLOGY Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI:10.3988/jcn.2023.0056
Jin-Man Jung, András Gruber, Peter Heseltine, Kumar Rajamani, Sebastián F Ameriso, Mark J Fisher
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引用次数: 0

摘要

感染与中风之间的关系尚未完全定性,这可能延误了特定治疗方法的开发。本叙述性综述探讨了与感染有关的中风机制,包括高凝状态、内皮功能障碍、血管炎和溶栓障碍。引起 COVID-19 的 SARS-CoV-2 病毒可能会促进中风的发生,而中风可能是其最严重的神经系统并发症。开发治疗感染相关中风的特效疗法仍是一项艰巨的挑战。剩下的最重要的问题或许就是如何区分引发中风的感染与真正偶然发生的感染。这种区分可能需要建立适当的生物标志物,其中的候选生物标志物是纤维蛋白 D-二聚体和抗心磷脂/抗磷脂抗体水平的升高。这些候选生物标志物可能用于鉴别中风前的致病性感染,这是针对该综合征建立特异性疗法的前奏。
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New Directions in Infection-Associated Ischemic Stroke.

The relationship between infections and stroke has not been fully characterized, probably delaying the development of specific treatments. This narrative review addresses mechanisms of stroke linked to infections, including hypercoagulability, endothelial dysfunction, vasculitis, and impaired thrombolysis. SARS-CoV-2, the virus that causes COVID-19, may promote the development of stroke, which may represent its most severe neurological complication. The development of specific therapies for infection-associated stroke remains a profound challenge. Perhaps the most important remaining issue is the distinction between infections that trigger a stroke versus infections that are truly incidental. This distinction likely requires the establishment of appropriate biomarkers, candidates of which are elevated levels of fibrin D-dimer and anticardiolipin/antiphospholipid antibodies. These candidate biomarkers might have potential use in identifying pathogenic infections preceding stroke, which is a precursor to establishing specific therapies for this syndrome.

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来源期刊
Journal of Clinical Neurology
Journal of Clinical Neurology 医学-临床神经学
CiteScore
4.50
自引率
6.50%
发文量
0
审稿时长
>12 weeks
期刊介绍: The JCN aims to publish the cutting-edge research from around the world. The JCN covers clinical and translational research for physicians and researchers in the field of neurology. Encompassing the entire neurological diseases, our main focus is on the common disorders including stroke, epilepsy, Parkinson''s disease, dementia, multiple sclerosis, headache, and peripheral neuropathy. Any authors affiliated with an accredited biomedical institution may submit manuscripts of original articles, review articles, and letters to the editor. The JCN will allow clinical neurologists to enrich their knowledge of patient management, education, and clinical or experimental research, and hence their professionalism.
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