从流行病学角度看渐冻人症的变化。

IF 6.9 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Reviews in Endocrine & Metabolic Disorders Pub Date : 2024-08-01 Epub Date: 2024-02-10 DOI:10.1007/s11154-024-09875-z
Christian Rosendal, Mai Christiansen Arlien-Søborg, Eigil Husted Nielsen, Marianne Skovsager Andersen, Claus Larsen Feltoft, Caroline Kistorp, Olaf M Dekkers, Jens Otto Lunde Jørgensen, Jakob Dal
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引用次数: 0

摘要

肢端肥大症是一种罕见疾病,因此很难从流行病学角度进行准确量化。在这篇综合性文献综述中,我们比较了从流行病学角度研究肢端肥大症的不同方法,并描述了该疾病在流行病学变量、临床表现和死亡率方面的时间演变。在此基础上,我们得出结论:肢端肥大症的发病率、患病率和确诊年龄都在稳步上升,但不同研究之间存在很大差异。偶然病例数量的增加可能是发病率和确诊年龄增加的原因之一。肢端肥大症诊断时的临床特征趋向于较轻的疾病表型,治疗方案的进步已将肢端肥大症患者的死亡率降至与普通人群相似的水平。此外,死亡的根本原因已从心血管疾病转向恶性肿瘤疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The changing landscape of acromegaly - an epidemiological perspective.

Acromegaly is a rare disease and thus challenging to accurately quantify epidemiologically. In this comprehensive literature review, we compare different approaches to studying acromegaly from an epidemiological perspective and describe the temporal evolution of the disease pertaining to epidemiological variables, clinical presentation and mortality. We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mortality of patients with acromegaly to a level similar to that of the general population. Moreover, the underlying cause of death has shifted from cardiovascular to malignant neoplastic diseases.

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来源期刊
Reviews in Endocrine & Metabolic Disorders
Reviews in Endocrine & Metabolic Disorders 医学-内分泌学与代谢
CiteScore
14.70
自引率
1.20%
发文量
75
审稿时长
>12 weeks
期刊介绍: Reviews in Endocrine and Metabolic Disorders is an international journal dedicated to the field of endocrinology and metabolism. It aims to provide the latest advancements in this rapidly advancing field to students, clinicians, and researchers. Unlike other journals, each quarterly issue of this review journal focuses on a specific topic and features ten to twelve articles written by world leaders in the field. These articles provide brief overviews of the latest developments, offering insights into both the basic aspects of the disease and its clinical implications. This format allows individuals in all areas of the field, including students, academic clinicians, and practicing clinicians, to understand the disease process and apply their knowledge to their specific areas of interest. The journal also includes selected readings and other essential references to encourage further in-depth exploration of specific topics.
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