一名阵发性夜间血红蛋白尿患者的多处血栓形成。

IF 2.7 4区医学 Q2 HEMATOLOGY Hamostaseologie Pub Date : 2024-02-09 DOI:10.1055/a-2231-5277

Lennart Beckmann, Tobias D Faizy, Fabian Flottmann, Jens Fiehler, Carsten Bokemeyer, Lennart Well, Antonia Beitzen-Heineke, Florian Langer

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引用次数: 0

摘要

病例阵发性夜间血红蛋白尿症（PNH）是一种极其罕见的骨髓疾病，由磷脂酰肌醇聚糖 A 类基因获得性突变引起，导致细胞补体调节剂 CD55 和 CD59 的部分或全部缺失。

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Multisite Thrombosis in a Patient with Paroxysmal Nocturnal Hemoglobinuria.

Case: Paroxysmal nocturnal hemoglobinuria (PNH) is an extremely rare bone marrow disorder caused by acquired mutations in the phosphatidylinositol glycan class A gene, which lead to a partial or total loss of the cellular complement regulators CD55 and CD59.1 In addition to complement-mediated hemolysis and cytopenia, venous and arterial thromboses at multiple and/or unusual sites are a common complication and occur in up to 44% of patients in historic PNH cohorts.1 2.

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来源期刊

Hamostaseologie HEMATOLOGY-

CiteScore

5.50

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Hämostaseologie is an interdisciplinary specialist journal on the complex topics of haemorrhages and thromboembolism and is aimed not only at haematologists, but also at a wide range of specialists from clinic and practice. The readership consequently includes both specialists for internal medicine as well as for surgical diseases.