SARS-CoV-2 感染急性后遗症患者外周血单核细胞线粒体呼吸的改变。

IF 3.9 3区生物学 Q2 CELL BIOLOGY Mitochondrion Pub Date : 2024-02-09 DOI:10.1016/j.mito.2024.101849

Sahera Dirajlal-Fargo , David P Maison , Jared C Durieux , Anastasia Andrukhiv , Nicholas Funderburg , Kate Ailstock , Mariana Gerschenson , Grace A Mccomsey

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引用次数: 0

摘要

对无 COVID 病史（19 人）、有 COVID 病史但完全康复（20 人）和 PASC（20 人）的参与者的外周血单核细胞（PBMC）线粒体呼吸进行了体外测量。COVID + PASC+ 的线粒体平均基础呼吸量、ATP 连接呼吸量、最大呼吸量、剩余呼吸量、ATP 连接呼吸量和非线粒体呼吸量最高（p ≤ 0.04）。非线粒体呼吸、ATP 链接呼吸、基础呼吸、剩余呼吸能力和最大呼吸每增加一个单位，PASC 的预测几率就会增加 1% 到 6%。PBMC 线粒体功能障碍可能是 PASC 的病因之一。

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Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection

Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.

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来源期刊

Mitochondrion 生物-细胞生物学

CiteScore

9.40

自引率

4.50%

发文量

审稿时长

13.6 weeks

期刊介绍： Mitochondrion is a definitive, high profile, peer-reviewed international research journal. The scope of Mitochondrion is broad, reporting on basic science of mitochondria from all organisms and from basic research to pathology and clinical aspects of mitochondrial diseases. The journal welcomes original contributions from investigators working in diverse sub-disciplines such as evolution, biophysics, biochemistry, molecular and cell biology, genetics, pharmacology, toxicology, forensic science, programmed cell death, aging, cancer and clinical features of mitochondrial diseases.