压力和酒精下的记忆整合与碎片化

IF 4.3 2区 医学 Q1 NEUROSCIENCES Neurobiology of Stress Pub Date : 2024-02-08 DOI:10.1016/j.ynstr.2024.100615
Krystian B. Loetscher , Elizabeth V. Goldfarb
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引用次数: 0

摘要

压力会有力地影响我们形成记忆的方式,尤其是记忆在多大程度上被整合或置于潜在的时空和更广泛的知识架构中。这些不同的表征反过来又会对我们利用这些记忆指导以后行为的方式产生重大影响。令人费解的是,虽然压力在历史上一直被认为会促进记忆的分裂,导致记忆表征的脱节,但最近的研究表明,压力也能促进记忆的结合和整合。了解压力在何种情况下会促进记忆整合,将是解决这一差异并揭示压力影响日后行为的机制的关键。在这里,我们将从多个层面来研究记忆整合:将单个经验的内容联系在一起,在相关但不同的事件之间建立联系,以及将经验与预先存在的图式或因果结构感结合在一起。我们将讨论每种整合形式背后的神经和认知机制,以及有关压力、厌恶学习和负面情绪如何调节每种整合形式的研究结果。在这一分析中,我们发现压力确实可以促进每种形式的整合。我们还展示了记忆整合如何应用于理解酒精的影响,强调了现有的临床和临床前研究结果以及进一步研究的机会。最后,我们探讨了整合和分裂对以后记忆引导行为的影响,以及了解哪种类型的记忆表征会被强化以设计适当干预措施的重要性。
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Integrating and fragmenting memories under stress and alcohol

Stress can powerfully influence the way we form memories, particularly the extent to which they are integrated or situated within an underlying spatiotemporal and broader knowledge architecture. These different representations in turn have significant consequences for the way we use these memories to guide later behavior. Puzzlingly, although stress has historically been argued to promote fragmentation, leading to disjoint memory representations, more recent work suggests that stress can also facilitate memory binding and integration. Understanding the circumstances under which stress fosters integration will be key to resolving this discrepancy and unpacking the mechanisms by which stress can shape later behavior. Here, we examine memory integration at multiple levels: linking together the content of an individual experience, threading associations between related but distinct events, and binding an experience into a pre-existing schema or sense of causal structure. We discuss neural and cognitive mechanisms underlying each form of integration as well as findings regarding how stress, aversive learning, and negative affect can modulate each. In this analysis, we uncover that stress can indeed promote each level of integration. We also show how memory integration may apply to understanding effects of alcohol, highlighting extant clinical and preclinical findings and opportunities for further investigation. Finally, we consider the implications of integration and fragmentation for later memory-guided behavior, and the importance of understanding which type of memory representation is potentiated in order to design appropriate interventions.

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来源期刊
Neurobiology of Stress
Neurobiology of Stress Biochemistry, Genetics and Molecular Biology-Biochemistry
CiteScore
9.40
自引率
4.00%
发文量
74
审稿时长
48 days
期刊介绍: Neurobiology of Stress is a multidisciplinary journal for the publication of original research and review articles on basic, translational and clinical research into stress and related disorders. It will focus on the impact of stress on the brain from cellular to behavioral functions and stress-related neuropsychiatric disorders (such as depression, trauma and anxiety). The translation of basic research findings into real-world applications will be a key aim of the journal. Basic, translational and clinical research on the following topics as they relate to stress will be covered: Molecular substrates and cell signaling, Genetics and epigenetics, Stress circuitry, Structural and physiological plasticity, Developmental Aspects, Laboratory models of stress, Neuroinflammation and pathology, Memory and Cognition, Motivational Processes, Fear and Anxiety, Stress-related neuropsychiatric disorders (including depression, PTSD, substance abuse), Neuropsychopharmacology.
期刊最新文献
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